PMID: 6973608Aug 1, 1981Paper

Antibody-specific immunoregulation and the immunodeficiency of aging

The Journal of Experimental Medicine
N R Klinman

Abstract

Experiments were carried out to assess the role of naturally acquired antibody-specific immunoregulation in the immunodeficiency of aged individuals. It was found that greater than 50% of the primary dinitrophenyl-specific BALB/c B cells did not respond in carrier-primed 2-yr-old BALB/c adoptive hosts as compared with similarly primed younger recipients. Similar suppression was observed in carrier-primed younger BALB/c mice that had received 4 x 10(7) spleen cells from 2-yr-old BALB/c mice, as opposed to those that had received 4 x 10(7) spleen cells from younger mice. This diminution in responsiveness was noted only for syngeneic BALB/c B cells because B cells of strains differing from BALB/c in the heavy chain allotype-idiotype locus were not suppressed. These findings indicate that old, but not young, mice had developed the capacity to suppress primary B cells bearing receptors expressing much of the syngeneic antibody repertoire. This suppression may play an important causative role in the relatively poor humoral immune responsiveness of aged individuals.

References

Jun 1, 1977·Cellular Immunology·R E CallardL K Waters
Aug 1, 1972·The Journal of Experimental Medicine·N R Klinman
Aug 1, 1973·The Journal of Experimental Medicine·N R Klinman, R A Doughty
Jun 1, 1974·Life Sciences·K E Cheney, R L Walford

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Citations

Mar 15, 1990·Mechanisms of Ageing and Development·A SethV Udhayakumar
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T TsudaM E Weksler
Apr 1, 1983·The Journal of Experimental Medicine·D Zharhary, N R Klinman
Jul 1, 1995·The Journal of Experimental Medicine·R J Hodes
Feb 26, 1998·Immunological Reviews·N R Klinman, G H Kline
Jul 1, 2004·Arthritis Research & Therapy·Sara A Johnson, John C Cambier
Aug 1, 1989·Immunological Reviews·M E WekslerG W Siskind
Jan 1, 1983·Annals of the New York Academy of Sciences·G W SiskindE A Goidl
Jan 1, 1983·Annals of the New York Academy of Sciences·N R KlinmanD Zharhary
Jan 1, 1995·International Reviews of Immunology·N R Klinman, G J Thorbecke
Jan 5, 2005·Journal of Leukocyte Biology·R Lakshman ChelvarajanSubbarao Bondada
Nov 1, 1982·European Journal of Immunology·N A Speck, S K Pierce
May 1, 1982·European Journal of Immunology·N A Speck, S K Pierce
Sep 1, 1986·European Journal of Immunology·D Zharhary

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