Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study

Lancet Neurology
Nuria Gresa-ArribasJosep Dalmau

Abstract

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a severe but treatable autoimmune disorder which diagnosis depends on sensitive and specific antibody testing. We aimed to assess the sensitivity and specificity of serum and CSF antibody testing in patients with anti-NMDA receptor encephalitis, and the relation between titres, relapses, outcome, and epitope repertoire. In this observational study, we used rat brain immunohistochemistry and cell-based assays (CBA) with fixed or live NMDA receptor-expressing cells to determine the sensitivity and specificity of antibody testing in paired serum and CSF samples. Samples were obtained at diagnosis from patients with anti-NMDA receptor encephalitis and from control participants worldwide. We deemed a patient to be antibody positive if their serum, their CSF, or both tested positive with both immunohistochemistry and CBA techniques; we determined titres with serial sample dilution using brain immunohistochemistry. We examined samples from 45 patients (25 with good outcome [modified Rankin Scale, mRS 0-2], ten with poor outcome [mRS 3-6], and ten with relapses) at three or more timepoints. We determined the epitope repertoire in the samples of 23 patients with CBA expressing Gl...Continue Reading

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References

Nov 1, 1988·Stroke; a Journal of Cerebral Circulation·R F Bloch
Jul 1, 1995·Pediatric Neurology·M S HammerC V Stack
Oct 29, 2003·Pediatric Neurology·Akira KumakuraMasatoshi Ito
May 5, 2007·Nature Clinical Practice. Neurology·Lauren H SansingJosep Dalmau
Apr 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ethan G HughesRita J Balice-Gordon
Oct 26, 2010·Journal of Neurology·Michael S ZandiBelinda R Lennox
Dec 18, 2010·Lancet Neurology·Josep DalmauRita Balice-Gordon
Mar 9, 2011·Journal of Neurology·Harry AlexopoulosMarinos C Dalakas
Jul 23, 2011·Lancet Neurology·Angela VincentPatrick Waters
Dec 21, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A LekoubouJ Honnorat
Apr 25, 2012·Journal of Neurology·Graham MackayPaul Maddison
Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amy J GleichmanDavid R Lynch
Oct 4, 2012·The American Journal of Psychiatry·Joseph C MasdeuJosep Dalmau
Nov 21, 2012·The Journal of Pediatrics·Thaís ArmangueUNKNOWN Spanish Anti-N-methyl-D-Aspartate Receptor (NMDAR) Encephalitis Work Group
Mar 5, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Brenda B Suh-LailamAnne E Tebo
Apr 23, 2013·Lancet Neurology·Maarten J TitulaerJosep Dalmau
Aug 22, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·M PunjaM D Schwartz
Aug 31, 2013·Biological Psychiatry·Julia DeakinMichael S Zandi
Sep 10, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Yael HacohenMing J Lim
Oct 12, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Shekeeb S MohammadFabienne Brilot
Dec 10, 2013·Annals of Neurology·Thaís ArmangueJosep Dalmau

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Citations

Dec 24, 2013·Lancet Neurology·Andrew McKeon, Vanda A Lennon
Mar 29, 2014·Der Nervenarzt·O Stich, S Rauer
Jul 23, 2014·Current Opinion in Rheumatology·Heather Van Mater
Aug 26, 2014·The Psychiatric Clinics of North America·Tanya K MurphyJames F Leckman
Sep 16, 2014·Annals of Indian Academy of Neurology·Ashok Kumar KayalBaiakmenlang Synmon
Dec 17, 2014·Seminars in Pediatric Neurology·Divya S Khurana
Dec 3, 2014·Schizophrenia Research·Matthew S Kayser, Josep Dalmau
Oct 15, 2014·Orphanet Journal of Rare Diseases·Pedro AciénCarlos Martín-Estefanía
Jan 28, 2015·Brain Injury : [BI]·Lloyd Bradley
Dec 2, 2015·Experimental and Therapeutic Medicine·Kurt-Wolfram SühsMartin Stangel
Aug 26, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Eszter Lazar-Molnar, Anne E Tebo
Feb 3, 2016·Pediatric Emergency Care·Keith K AbeLoren G Yamamoto
Feb 26, 2016·Lancet Neurology·Francesc GrausJosep Dalmau
Oct 28, 2015·Annals of Neurology·Esther Castillo-GomezHannelore Ehrenreich
Jan 30, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R ConstantinescuH Zetterberg
Jan 24, 2016·Indian Journal of Pediatrics·Renu SutharPratibha Singhi
Oct 21, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Hans C van MierloUNKNOWN GROUP investigators
Feb 24, 2016·Internal Medicine Journal·M P NewmanD Gillis
Dec 23, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Matteo GastaldiAngela Vincent
May 24, 2014·Annals of Neurology·Liane DahmHannelore Ehrenreich
Dec 30, 2014·Clinical and Experimental Immunology·M R Rosenfeld
Jan 13, 2016·Journal of Clinical Neurology·Eric Lancaster
Aug 28, 2015·Scientific Reports·H PrüssA D Greenwood
Jun 17, 2015·Seizure : the Journal of the British Epilepsy Association·Rui WangDong Zhou
Nov 29, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Katherine BeckOliver D Howes
Jul 22, 2014·Annals of Neurology·Maarten J TitulaerJosep Dalmau
Apr 5, 2014·Annals of Neurology·Maarten J TitulaerJosep Dalmau
Jun 17, 2014·Annals of Neurology·Sarosh R IraniAngela Vincent
Oct 16, 2014·Annals of the New York Academy of Sciences·Frank LeypoldtJosep Dalmau
Oct 16, 2015·Molecular Brain·Kurt-Wolfram SühsKirsten Müller-Vahl
Sep 4, 2015·Current Opinion in Oncology·Romana HöftbergerJosep Dalmau
Mar 31, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ying-Ying WuJie-Wen Zhang
Aug 16, 2015·Autonomic Neuroscience : Basic & Clinical·Jung-Ick ByunKon Chu
Apr 1, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Maude-Marie Gagnon, Martin Savard
Oct 23, 2015·Neurology·Thaís ArmangueUNKNOWN Spanish Prospective Multicentric Study of Autoimmunity in Herpes Simplex Encephalitis
Nov 26, 2015·Neurology. Neuroimmunology and Neuroinflammation·Peter MaatPeter Sillevis Smitt
May 16, 2015·Psychosomatics·Jennifer L KruseAndrew McKeon
Sep 16, 2015·Acta Psychiatrica Scandinavica·H C van MierloL D de Witte
Jul 22, 2014·Developmental Medicine and Child Neurology·Sarah TatenclouxKumaran Deiva
Apr 18, 2015·Biochimica Et Biophysica Acta·Bastien Joubert, Jérôme Honnorat
Jun 28, 2016·Pediatric Neurology·J Nicholas Brenton, Howard P Goodkin
Aug 27, 2015·Neurology. Neuroimmunology and Neuroinflammation·Melanie RambergerMarkus Reindl

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