PMID: 7541842Aug 1, 1995Paper

Antibody to adhesion molecule LFA-1 enhances plasma neutralization of human immunodeficiency virus type 1

Journal of Virology
M B Gomez, J E Hildreth

Abstract

We have shown that a monoclonal antibody to the cell surface adhesion molecule LFA-1 (CD18/CD11a) enhances plasma neutralization of a laboratory isolate (HIVMN) and a primary isolate (HIV28R) of human immunodeficiency virus type 1. Human phytohemagglutinin blasts were infected with HIVMN or HIV28R in the presence of plasma pooled from HIV-positive individuals (AIDS plasma) or immunoglobulin G from AIDS plasma alone or combined with a monoclonal antibody (MAb) to LFA-1. While AIDS plasma alone at a dilution of 1:1,250 neutralized HIVMN and HIV28R infection by 15 and 0%, respectively, in the presence of a saturating concentration of the MAb to LFA-1 the plasma neutralized both viruses by more than 80% at this dilution. Immunoglobulin G purified from AIDS plasma, when used in combination with the MAb to LFA-1, showed the same synergistic effect in HIV neutralization as seen with the AIDS plasma and anti-LFA-1. The MAb against LFA-1 partially neutralized both viral isolates (45 to 55%) on its own. These results demonstrate significant synergy between the plasma and antibody against LFA-1 in the neutralization of HIV. The observations therefore suggest an important role for adhesion molecules in HIV infectivity and transmission. The...Continue Reading

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Citations

Aug 4, 2001·AIDS Research and Human Retroviruses·Z LiaoJ E Hildreth
Apr 30, 1999·AIDS Research and Human Retroviruses·M SpruthM P Dierich
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean-François GiguèreMichel J Tremblay
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