PMID: 641208Apr 1, 1978Paper

Antibody to hepatitis B surface antigen in haemophiliacs on long-term therapy with Scottish factor VIII

Journal of Clinical Pathology
C J BurrellD M Ramsay

Abstract

Thirty-five patients with haemophilia A were studied clinically and serologically between 1971-2 and 1975-6 for evidence of hepatitis B infection. One patient suffered from clinical hepatitis B, and a further eight patients showed antibody responses to hepatitis B surface antigen (HBsAg) consistent with exposure to HBsAg during this period. No evidence for HBsAg exposure was found in 14 patients, while the remaining 12 patients had high titres of antibody to HBsAg at both times and no inferences could be drawn about HBsAg exposure. All patients had received exclusively replacement factor VIII material prepared locally from HBsAg-screened voluntary Scottish blood donations. From the details of the therapy given we calculated that the rate of HBsAg seroconversion in these patients represented about 0.3 HBsAg-containing donations/1000 donations.

References

Sep 1, 1975·The American Journal of the Medical Sciences·M GoldfieldW Pizzuti
Apr 1, 1974·Journal of Clinical Pathology·C J BurrellE Proudfoot

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Citations

Nov 27, 1982·Lancet·G S GabraR Mitchell
Nov 27, 1982·Lancet·K MuhiddinA J Camm
Apr 1, 1979·Journal of Clinical Pathology·B A McVerryJ Voke
Oct 1, 1980·Journal of Clinical Pathology·S De VirgiliisA Cao
May 1, 1983·Journal of Clinical Pathology·M L StirlingC A Ludlam
Apr 2, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·M SteeleL Ford-Jones
Mar 16, 2011·Muscle & Nerve·Theodoros KyriakidesEleftherios S Papathanasiou

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