PMID: 6968757Jul 1, 1980Paper

Antibody to synthetic poly dAT: correlation with antibody to native DNA and specificity for SLE

Journal of Clinical Pathology
P Davis, D Makinen

Abstract

Antibodies to synthetic 3H-poly dAT have the advantage over antibody to native DNA in that they have a higher degree of specificity for systemic lupus erythematosus (SLE). This is because poly dAT eliminates the problem of measurement of single stranded antibodies that are not specific for any one condition but which may be detected by native DNA preparations which usually contain single stranded regions. The overall degree of correlation between the two antibodies is good in SLE. Antibodies to poly dAT correlate well with clinical evidence of disease activity but in this study were not particularly associated with the presence of renal disease.

References

Sep 1, 1976·Arthritis and Rheumatism·R W Lightfoot, G R Hughes
May 10, 1976·The American Journal of Medicine·K D NolphA W Siemsen
Sep 1, 1976·Arthritis and Rheumatism·K LentzP Barland
Nov 27, 1974·Biochemical and Biophysical Research Communications·A R Morgan, D E Pulleyblank
Nov 1, 1970·Arthritis and Rheumatism·V HansonH Kornreich
May 1, 1971·Annals of the Rheumatic Diseases·G R HughesC L Christian
Jul 1, 1971·The Journal of Experimental Medicine·D KofflerH G Kunkel
Dec 30, 1971·The New England Journal of Medicine·W V EpsteinM Easterbrook
Sep 25, 1969·The New England Journal of Medicine·T PincusN Talal
Dec 28, 1966·Journal of Molecular Biology·O W Jones, P Berg
Jul 18, 1963·Biochemical and Biophysical Research Communications·A P NYGAARD, B D HALL

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