Antibody treatment of lower respiratory tract infections

Seminars in Respiratory Infections
S J Skerrett

Abstract

Antibody treatment of lower respiratory infection has a long history of success and is receiving renewed interest. A variety of polyclonal and monoclonal preparations are clinically available. Although used primarily for infection prophylaxis, these agents have limited applications in the treatment of established infections. Immune serum was the first effective treatment for pneumococcal pneumonia. Although long-supplanted by the advent of antibiotics, passive immunotherapy for pneumococcal and other infections is being revisited in an era of increasing antibiotic resistance and growing numbers of immunocompromised individuals. Limited clinical evidence supports the use of immune globulins in the treatment of pertussis and severe streptococcal infection. Bone marrow transplant recipients with lower respiratory infections caused by cytomegalovirus or respiratory syncytial virus also may benefit by adjunctive treatment with immune globulins. Additional indications for antibody treatment of respiratory infection may develop with further investigation.

Citations

Apr 12, 2003·Current Opinion in Pulmonary Medicine·Julie AndrewsNandini Shetty
Mar 3, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·UNKNOWN Committee for the Japanese Respiratory Society Guidelines in Management of Respiratory
Sep 8, 2009·Antiviral Research·Ian J Amanna, Mark K Slifka
Feb 21, 2007·Expert Opinion on Pharmacotherapy·Douglas M Fleming, Alex J Elliot

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