Anticalcification effect of a combination of decellularization, organic solvents and amino acid detoxification on glutaraldehyde-fixed xenopericardial heart valves in a large-animal long-term circulatory model

Interactive Cardiovascular and Thoracic Surgery
Chun Soo ParkNayun Kwon

Abstract

We aimed to investigate the effect of a combination of anticalcification treatments, which were effective for preventing calcification in a small animal experiment, on glutaraldehyde-fixed xenopericardial valves using a large-animal long-term circulatory model. Valved conduits were made of porcine pericardium as a leaflet and bovine pericardium as a conduit and were implanted into the right ventricular outflow tract of goats under cardiopulmonary bypass. The goats were divided into study (glutaraldehyde + combined anticalcification treatment, n = 6) and control (glutaraldehyde alone, n = 9) groups. Upon euthanization at 1 year, echocardiography and cardiac catheterization were performed. Explanted tissues were microscopically examined and analysed for measuring the calcium content. Haemodynamic data were obtained from 3 and 2 goats in the study and control groups, respectively. All valves, except 1, which was limited in motion, were functioning well on echocardiography; pressure gradients across the right ventricular outflow tract were lower in the study group on cardiac catheterization. On gross inspection, all leaflets remained mobile without calcific deposits in the study group, while most leaflets were heavily calcified in ...Continue Reading

References

Jan 1, 1991·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·G GongR W Frater
Aug 1, 1994·Biomaterials·E Jorge-HerreroJ L Castillo-Olivares
Mar 1, 1996·Biomaterials·E Jorge-HerreroJ L Castillo-Olivares
Oct 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·P MacchiariniP Dartevelle
Dec 6, 2002·The American Journal of Pathology·Susan A SteitzCecilia M Giachelli
Jun 18, 2003·Biomaterials·Kyoung Soo JeeYoung Ha Kim
Dec 2, 2004·Expert Opinion on Biological Therapy·Dan T Simionescu
Jan 11, 2005·European Journal of Clinical Investigation·K Z KonakciH J Ankersmit
Jun 14, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Elena PettenazzoGaetano Thiene
Jan 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Pia S U Mykén, Odd Bech-Hansen
Aug 12, 2009·The Thoracic and Cardiovascular Surgeon·A MangoldH J Ankersmit
Aug 27, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Cheul LeeYong Jin Kim
Jun 21, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hong-Gook LimYong Jin Kim

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Citations

Jul 4, 2019·Journal of Cardiac Surgery·E Andreas AgathosPetros G Koutsoukos
Mar 20, 2019·Biomedical Engineering Online·Michael Meyer
Sep 20, 2020·Journal of Cardiothoracic Surgery·Steve W F R WaqanivavalagiJillian Cornish
Oct 11, 2020·Environmental Science and Pollution Research International·Ahmed S MandourGen Watanabe
Mar 24, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Robin AugustinePablo Maureira

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