Anticancer activity of Helicobacter pylori ribosomal protein (HPRP) with iRGD in treatment of colon cancer.

Journal of Cancer Research and Clinical Oncology
Atieh YaghoubiSaman Soleimanpour

Abstract

As the conventional therapeutic approaches were not completely successful in the treatment of colon cancer, there is still a need for finding the most efficient therapeutic agents. Here we investigated the anticancer activity of HPRP-A1 that was derived from the N-terminal region of Helicobacter pylori ribosomal protein L1 (RpL1) alone or in combination with tumor-homing peptide iRGD and 5-Fluorouracil (5FU) on colon cancer cell lines (CT26 and HT29) and isograft models of colon cancer. We assessed the tumor growth inhibitory activity of HPRP-A1 with or without iRGD and 5FU on colon cancer in vitro and in vivo. In the in vitro part, we investigate the effect of HPRP-A1 alone and in combination with iRGD/5FU. Our results demonstrated that co-administration of HPRP-A1 with iRGD increased the apoptosis, while these two peptides in combination with 5FU increased the intracellular level of p53 that upregulate the pro-apoptotic gene BAX and downregulate the anti-apoptotic gene BCL2. HPRP-A1 blocks the cell cycle progression in G0/G1. Co-administration of two peptides significantly reduced the size and weight of the tumors, while the group that received 5FU in combination with the peptides increased the necrotic and decrease the fibro...Continue Reading

References

Jan 1, 1984·Methods in Enzymology·H Aebi
May 5, 1999·Nature·K PütsepS Normark
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·J L WangZ Huang
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Claudio HetzRosalba Lagos
Jan 16, 2004·The New England Journal of Medicine·Marc LecuitOlivier Lortholary
Apr 5, 2005·Nature Reviews. Microbiology·Alistair J Lax
Mar 7, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Minoru Fujimori
Nov 23, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ming Q WeiBert Vogelstein
Nov 3, 2007·Vascular Pharmacology·Shahrzad ElmiIsmail Laher
May 1, 2008·Physiological Genomics·Eun-Soo HanArlan Richardson
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tambet TeesaluErkki Ruoslahti
Dec 8, 2009·Cancer Cell·Kazuki N SugaharaErkki Ruoslahti
Nov 19, 2010·World Journal of Gastroenterology : WJG·Gopal NathVijay K Shukla
Mar 17, 2011·Nature Communications·Ole Audun Werner HaabethAlexandre Corthay
Jun 26, 2012·Current Medicinal Chemistry·R J BoohakerA R Khaled
Jun 12, 2013·Clinical & Experimental Metastasis·Yu ZhangMaria Marjorette O Peña
Aug 30, 2013·Frontiers in Oncology·Tambet TeesaluErkki Ruoslahti
Dec 5, 2013·Journal of the National Cancer Institute·Elisa GiovannettiGiuseppe Giaccone
Aug 15, 2014·Science Translational Medicine·Nicholas J RobertsShibin Zhou
Apr 15, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Amanda M HamiltonBrian K Rutt
Jul 28, 2015·PloS One·Libo YanSusumu Terakawa
Feb 13, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wang QifanZhang Ge
Mar 5, 2016·Oncoimmunology·Ole Audun Werner HaabethAlexandre Corthay
Apr 5, 2016·Advanced Drug Delivery Reviews·Erkki Ruoslahti
Sep 30, 2016·World Journal of Gastroenterology : WJG·Lieselotte LemoineKurt Van der Speeten
Mar 23, 2017·Journal of Biomedical Science·Susan MarqusTerrence J Piva
Feb 6, 2018·Apoptosis : an International Journal on Programmed Cell Death·Cuihua HuYuxin Chen
May 9, 2018·Journal of Cellular Physiology·Reyhaneh Moradi MarjanehMajid Khazaei
Oct 13, 2018·Scientific Reports·Qinlian HouDeguan Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis