Anticancer activity of Morinda citrifolia (Noni) fruit: a review

Phytotherapy Research : PTR
Amy C Brown

Abstract

This review investigated the relationship of noni juice, or its extract (fruit, leaves or root), to anticancer and/or immunostimulant properties. A Medline search was conducted using the key search words 'Morinda citrifolia' and 'Morinda citrifolia and cancer' (1964 to October, 2011) along with cross-referencing. Botanical and chemical indexes were not included. A total of 304 and 29 (10%) articles, respectively, were found under these key terms. Of the 19 studies actually related to cancer, seven publications were in vitro cancer studies, nine were in vivo animal cancer studies, and three were in vivo human cancer studies. Among the in vitro studies, a 'concentrated component' in noni juice and not pure noni juice may (1) stimulate the immune system to 'possibly' assist the body fight the cancer, and (2) kill a small percentage (0-36%) of cancer cells depending on the type. The nine animal studies suggest that a concentrated component in noni juice may stimulate the immune system; but only slightly increases the number (about 1/3; 25-45%) of surviving mice. Other than two case studies, only two human clinical studies existed. The first consisted of testing freeze-dried noni fruit, which reduced pain perception, but did not rev...Continue Reading

References

Dec 22, 1999·Journal of Agricultural and Food Chemistry·M WangC T Ho
Feb 17, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B A MuellerK A Prag
Sep 9, 2000·Journal of Natural Products·M WangC T Ho
Apr 21, 2001·AIDS Patient Care and STDs
Jan 25, 2002·Annals of the New York Academy of Sciences·M Y Wang, C Su
Nov 1, 2002·Phytotherapy Research : PTR·Jonel P SaludesAlicia M Aguinaldo
Jan 25, 2003·Journal of Natural Products·Kanyanga CimangaArnold Vlietinck
Jul 23, 2003·Journal of Plant Physiology·Marc StalmanAnton F Croes
Aug 13, 2004·American Journal of Hematology·Marcus E CarrMichael Bergeron
Sep 29, 2004·Neurology·Eliot M Wallack, Robert Callon
Dec 4, 2004·Biotechnology Progress·Artiwan ShotiprukMitsuru Sasaki
Mar 10, 2005·European Journal of Gastroenterology & Hepatology·Gunda MillonigWolfgang Vogel
Apr 23, 2005·Journal of Natural Products·Bao-Ning SuA Douglas Kinghorn
Jul 13, 2005·Advances in Chronic Kidney Disease·Jerrilynn D Burrowes, Gloria Van Houten
Aug 12, 2005·World Journal of Gastroenterology : WJG·Vanessa StadlbauerRudolf E Stauber
Dec 6, 2005·Ultrasonics Sonochemistry·Surasak HemwimolArtiwan Shotipruk
Dec 6, 2005·Chemical & Pharmaceutical Bulletin·Kohei KamiyaToshiko Satake
Apr 19, 2006·Phytotherapy Research : PTR·Teerakul Arpornsuwan, Tadsanee Punjanon
Jun 15, 2006·World Journal of Gastroenterology : WJG·Brett-J WestJohannes Westendorf
Jun 17, 2006·Phytochemistry·Anh Kim T BuiFilomena Pettolino
Aug 15, 2006·Biochemical and Biophysical Research Communications·Masakazu KamataIrvin S Y Chen
Aug 17, 2006·Journal of Agricultural and Food Chemistry·Volodymyr SamoylenkoIlias Muhammad
Nov 23, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P T MpianaK N Ngbolua
Nov 28, 2006·International Journal of Food Sciences and Nutrition·Isabella CalzuolaValeria Marsili
Nov 28, 2006·Natural Product Research·Bina S SiddiquiFayaz Ahmad
Jan 5, 2007·Journal of Medicinal Food·Narayanasamy MathivananKannan Malarvizhi
Jan 18, 2007·Journal of Agricultural and Food Chemistry·Johannes WestendorfSimla Basar
Feb 3, 2007·Chemical & Pharmaceutical Bulletin·Junko TakashimaAyumi Ohsaki
Feb 9, 2007·Planta medica·Olivier Potterat, Matthias Hamburger
Feb 27, 2007·Journal of Wound Care·B S NayakD D Ramdath
Dec 7, 2007·The Journal of Pharmacy and Pharmacology·Alison D Pawlus, Douglas A Kinghorn
Oct 11, 2008·The American Journal of Gastroenterology·Vanessa StadlbauerRudolf E Stauber
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·B Shivananda NayakAnderson Maxwell
May 13, 2009·Phytotherapy Research : PTR·Afa PaluJarakae Jensen
Jun 24, 2009·Phytotherapy Research : PTR·Simla BasarJohannes Westendorf
Sep 1, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Aree JainkittivongRobert P Langlais
Oct 3, 2009·The Journal of Toxicological Sciences·Brett J WestC Jarakae Jensen

❮ Previous
Next ❯

Citations

Feb 23, 2002·Natural Product Letters·N Jahan Atta-Ur-Rahman
Oct 13, 2014·Food Chemistry·Amadeo Gironés-VilaplanaCristina García-Viguera
Jan 23, 2013·Complementary Therapies in Clinical Practice·Shanoo Suroowan, Fawzi Mahomoodally
Jan 20, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Yougen WuGhee T Tan
Sep 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pratibha V NerurkarErik Saksa
Feb 7, 2015·Molecular Immunology·Javier A Garcia-VilasGianni Garcia-Faroldi
Dec 17, 2019·Phytotherapy Research : PTR·Bharat Singh, Ram A Sharma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.