Anticancer activity of Neptunia oleracea methanolic extracts.

Natural Product Research
Archana BhumireddyKrishna Satya Alapati

Abstract

Neptunia oleracea Lour (water mimosa) is an edible medicinal plant used in treating various diseases. According to Phytochemical and Ethnobotanical Databases, Neptunia oleracea Lour is used in curing earaches, dysentery, syphilis, and tumour. The present study was aimed at demonstrating the anticancer activity of the Neptunia oleracea Lour methanolic extract. The methanolic extract was isolated and its anti-proliferative activity was studied on haematological cancer cell lines. The activity of the extract was further evaluated using cell cycle analysis and apoptosis assays. In addition to this, effect of the extract on c-Myc and PErk1/2 modulation was also evaluated. Neptunia oleracea Lour extract induced cell death in cancer cells while sparing normal cells. An increase in cleaved PARP and reduction in BCL-2 levels observed upon treatment. Neptunia oleracea causes reduction in c-Myc levels and pERK1/2 protein levels. Thus, our work highlights the methanolic extract of Neptunia oleracea Lour as a promising anti-cancer agent.

References

Jun 23, 1999·Oncogene·C E NesbitE V Prochownik
Jul 26, 2003·Journal of Natural Products·David J NewmanKenneth M Snader
Nov 15, 2008·Nutrition and Cancer·Manjinder KaurChapla Agarwal
Nov 7, 2009·Brazilian Oral Research·Ricardo Carneiro BorraPriscila Maria Andrade
Mar 8, 2011·Microbial Biotechnology·Arnold L Demain, Preeti Vaishnav
Apr 16, 2011·Leukemia·L S SteelmanJ A McCubrey
Mar 13, 2018·Signal Transduction and Targeted Therapy·Hui ChenGuoliang Qing
Feb 23, 2019·Cell Death & Disease·Chloe F A WarrenNikola A Bowden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis