Anticancer cellular immunotherapies derived from umbilical cord blood

Expert Opinion on Biological Therapy
Katalin Balassa, Vanderson Rocha

Abstract

The lack of highly effective drugs in many malignancies has prompted scientific interest in the development of alternative treatment strategies. Cellular immunotherapy involving the adoptive transfer of immune cells that potently recognize and eliminate malignantly transformed cells has become a promising new tool in the anticancer armory. Studies suggest that the unique biological properties of umbilical cord blood (UCB) cells could precipitate enhanced anticancer activity; hence, UCB could be an optimal source for immunotherapy with the potential to provide products with 'off-the-shelf' availability. In this review, the authors summarize data on the transfer of naturally occurring or genetically modified UCB cells to treat cancer. The focus within is on the phenotypic and functional differences compared to other sources, the alloreactive and anticancer properties, and manufacturing of these products. Therapies utilizing cytokine-induced killer (CIK) cells, natural killer (NK) cells and chimeric antigen receptor (CAR) T-cells, are discussed. The cellular immunotherapy field has become a growing, exciting area that has generated much enthusiasm. There is evidence that anticancer immunotherapy with UCB-derived products is feasib...Continue Reading

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Citations

Apr 18, 2019·Journal of Cellular Physiology·Behnaz ValipourHojjatollah Nozad Charoudeh
Jun 13, 2020·Expert Opinion on Biological Therapy·Mattia AlgeriFranco Locatelli
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Jul 23, 2020·Molecular Therapy. Methods & Clinical Development·Yan YangDongfang Liu
Apr 27, 2021·Molecular Therapy. Methods & Clinical Development·Vania Lo PrestiNiek P van Til

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