Anticancer Characteristics of Fomitopsis pinicola Extract in a Xenograft Mouse Model-a Preliminary Study

Nutrition and Cancer
Chi H J KaoKaren S Bishop

Abstract

Introduction: Medicinal mushrooms have been used for the treatment of diseases and general promotion of health for many centuries. Recent pharmacological research into medicinal mushrooms has identified various therapeutic properties, with applications in modern medicine.Aim: To evaluate the anti-cancer activities of Fomitopsis pinicola (F. pinicola) alcoholic extract in an in vivo setting.Methods: The anti-tumour effect of the F. pinicola extract was tested in a xenograft immune-compromised Rag-1 mouse model. This was followed by RT-PCR and metabolomics analyses.Results: There were no observable differences in tumor growth between treated and non-treated groups. The bioactive components were not detected in the mouse plasma or the tumor site.Conclusions: The extract was poorly absorbed; this is likely due to the timing of treatment, dosage levels and modifications made to the extract where the alcohol-based solvent was replaced with water. This, in combination with fractionation studies which identified most anti-cancer compounds to be hydrophobic, largely explained the lack of anti-cancer activities in vivo.

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Nov 1, 1989·CA: a Cancer Journal for Clinicians·D G Bostwick
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 2, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Ulrike LindequistWolf-Dieter Jülich
Sep 30, 2009·Molecular and Cellular Biology·Nikia LaurieMichael A Dyer
Jul 29, 2011·Methods in Molecular Biology·Albert O Brinkmann
May 15, 2012·3 Biotech·Seema Patel, Arun Goyal
Jul 26, 2012·ISRN Pharmaceutics·Ketan T SavjaniJignasa K Savjani
Jan 24, 2014·Cancer Metastasis Reviews·Magdalena M GrabowskaRobert J Matusik
Feb 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hung-Tsung WuChih-Jen Chang
May 9, 2014·The Journal of Nutrition·Mary Jo FeeneyDayong Wu
Dec 15, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ye GaoQuanhong Liu

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Methods Mentioned

BETA
xenograft
xenografting

Software Mentioned

SIEVE
Affymetrix
GraphPad Prism
SigmaPlot
Excel
MaxQuant

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