Anticancer effect of Kalpaamruthaa on mammary carcinoma in rats with reference to glycoprotein components, lysosomal and marker enzymes

Biological & Pharmaceutical Bulletin
Krishnamurthy VeenaP Sachdanandam

Abstract

A promising approach to reduce the occurrence of cancer is its treatment, specifically by chemical intervention through minor dietary constituents. Epidemiological studies suggest that specific pharmacologically active agents present in the diet might reduce cancer. A remarkable surge of interest in chemoprevention research has, thus, lead to the identification of many phytochemicals of dietary origin as effective potential chemotherapeutic agents. In the present investigation, attempt has been made to study the potency of Kalpaamruthaa (KA), a herbal preparation, against cancer. The changes in level of glycoprotein components, marker enzymes and lysosomal enzymes were carried out in 7,12-dimethylbenz(a)anthracene (DMBA) induced Sprague-Dawley rats. The changes in the body weights and volume were also determined. KA was administered at the dosage level of 100, 200, 300, 400 and 500 mg/kg body weight (BW) in olive oil orally for 14 d, after the induction period is completed (90 d). On administration of KA, the levels of the above enzymes and the changes in the body weights and volume were significantly normalized in a dose dependent manner. The present study shows that KA is effective at the dosage level of 300 mg/kg body weight...Continue Reading

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Citations

Oct 15, 2013·Canadian Journal of Physiology and Pharmacology·Raja LathaPanchanadham Sachdanandam
Sep 16, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shevali KansalNavneet Agnihotri
Jul 26, 2008·Journal of Photochemistry and Photobiology. B, Biology·D Gayathri DeviAnnie Abraham
Apr 9, 2008·Chemico-biological Interactions·Rajendran MythilypriyaPanchanadam Sachdanandam
Apr 22, 2006·Chemico-biological Interactions·Krishnamurthy VeenaPanchanatham Sachdanandam
Aug 30, 2008·Chemico-biological Interactions·Rajendran MythilypriyaPanchanadam Sachdanandam
Jun 25, 2016·Chinese Journal of Integrative Medicine·Shanthi PalaniveluSachdanandam Tiruvaiyaru Panchanadham
Aug 10, 2006·Molecular and Cellular Biochemistry·Krishnamurthi VeenaPanchanatham Sachdanandam

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