Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis

Biological & Pharmaceutical Bulletin
Parash ParajuliPaul W Sylvester

Abstract

Aerobic glycolysis is an established hallmark of cancer. Neoplastic cells display increased glucose consumption and a corresponding increase in lactate production compared to the normal cells. Aerobic glycolysis is regulated by the phosphatidylinositol-3-kinase (PI3K)/Akt/ mammalian target of rapamycin (mTOR) signaling pathway, as well as by oncogenic transcription factors such as c-Myc and hypoxia inducible factor 1α (HIF-1α). γ-Tocotrienol is a natural isoform within the vitamin E family of compounds that displays potent antiproliferative and apoptotic activity against a wide range of cancer cell types at treatment doses that have little or no effect on normal cell viability. Studies were conducted to determine the effects of γ-tocotrienol on aerobic glycolysis in mouse +SA and human MCF-7 breast cancer cells. Treatment with γ-tocotrienol resulted in a dose-responsive inhibition of both +SA and MCF-7 mammary tumor cell growth, and induced a relatively large reduction in glucose utilization, intracellular ATP production and extracellular lactate excretion. These effects were also associated with a large decrease in enzyme expression levels involved in regulating aerobic glycolysis, including hexokinase-II, phosphofructokinase,...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Sep 1, 1981·European Journal of Cancer & Clinical Oncology·L W AndersonH L Hosick
Aug 30, 2000·Proceedings of the Society for Experimental Biology and Medicine·B S McIntyreP W Sylvester
Apr 3, 2002·Trends in Molecular Medicine·Gregg L Semenza
Feb 24, 1956·Science·O WARBURG
Nov 2, 2004·Nature Reviews. Cancer·Robert A Gatenby, Robert J Gillies
Mar 5, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Sumit J Shah, Paul W Sylvester
Jan 8, 2008·Cell Metabolism·Ralph J DeBerardinisCraig B Thompson
Apr 11, 2009·Experimental Biology and Medicine·Vikram B WaliPaul W Sylvester
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Sep 23, 2009·Apoptosis : an International Journal on Programmed Cell Death·Vikram B WaliPaul W Sylvester
Oct 29, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chi V DangPing Gao
Dec 19, 2009·The Journal of Biological Chemistry·Yongjun FanWei-Xing Zong
Feb 17, 2010·The International Journal of Biochemistry & Cell Biology·Sybille Mazurek
Feb 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Qian SunHongbing Zhang
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Dec 6, 2011·Journal of Bioanalysis & Biomedicine·Amit B Shirode, Paul W Sylvester
Sep 27, 2012·Cancer Discovery·Jason R Cantor, David M Sabatini
Mar 12, 2013·International Journal of Cell Biology·Nicholas WongDamu Tang
Jun 28, 2013·BioFactors·Paul W SylvesterNehad M Ayoub
Sep 4, 2013·The Journal of Clinical Investigation·Joanne R Doherty, John L Cleveland
Nov 16, 2013·Experimental Biology and Medicine·Roshan V TiwariPaul W Sylvester
Dec 5, 2013·Molecular Cancer·Shanmugasundaram Ganapathy-Kanniappan, Jean-Francois H Geschwind
Aug 21, 2014·BioMed Research International·Suryatheja AnanthulaPaul W Sylvester
Jan 1, 2014·Molecular Therapy. Methods & Clinical Development·Pradip BajgainJuan F Vera

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Citations

Aug 2, 2018·Journal of Cellular Physiology·Marina Montagnani MarelliPatrizia Limonta
Jun 22, 2017·Future Medicinal Chemistry·Qingbin CuiPeng Huang
Jan 20, 2016·European Journal of Clinical Investigation·Ana F BrancoTeresa Cunha-Oliveira
Apr 9, 2019·Nutrition and Cancer·Venkateshwara DronamrajuPaul W Sylvester
May 1, 2021·Antioxidants·Anca UngurianuDenisa Margină
Jan 10, 2018·Journal of Agricultural and Food Chemistry·Yang LuYue Geng

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