Anticancer effects of a tertiary sulfonium compound, dimethylsulfoniopropionate, in green sea algae on Ehrlich ascites carcinoma-bearing mice

Journal of Nutritional Science and Vitaminology
Kenji NakajimaYoshiki Nakajima

Abstract

The saline and dimethylsulfoniopropionate (DMSP) solutions at 5, 10 and 20 mM were preliminarily injected intraperitoneally every other day into two control and three DMSP groups of mice (n=8) for 2 wk and thereafter Ehrlich ascites-carcinoma (EAC) cells were peritoneally injected to one control and three DMSP groups of mice, leaving one control group without the EAC injection. Then, the body weight and survival time of all mice were examined over a long rearing time up to 300 d. All EAC-bearing mice, especially the carcinoma control and 5 mM DMSP-carcinoma group mice, rapidly increased their body weights early and then died by day 50 and day 90, respectively. In contrast, the administration of 10 and 20 mM DMSP solutions prolonged the lives of EAC-bearing mice at the survival rate of 50 and 63% respectively up to 300 d without any side effects. Furthermore, the administration of 10 mM DMSP solution proved to activate the delayed-type hypersensitivity of EAC bearing-mice, and the DMSP solutions over the concentrations of 5 to 30 mM to slightly reduce the dead cells in EAC cells on the synthetic medium. Accordingly, the preliminary supplementation of 10 and 20 mM DMSP solutions to EAC-bearing mice was proven to maintain their li...Continue Reading

References

Jun 1, 1991·Journal of Nutritional Science and Vitaminology·K Nakajima
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May 13, 2005·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Hirota Fujiki
Apr 28, 2006·Journal of Nutritional Science and Vitaminology·Kenji Nakajima
Apr 28, 2006·Journal of Nutritional Science and Vitaminology·Kenji Nakajima, Masaharu Minematsu
Jan 30, 2009·Journal of Gastroenterology and Hepatology·Takafumi IchikawaKazuhiko Ishihara
Feb 7, 2009·Environmental and Molecular Mutagenesis·Xin-Jiang WuVolker Mersch-Sundermann

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Citations

Jun 4, 2013·Cancer Cell International·Jin-Ching LeeHsueh-Wei Chang
Apr 17, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Meenakshi SundaramGunasingham Maniarasu
Apr 23, 2011·Bioscience, Biotechnology, and Biochemistry·Kenji Nakajima, Yoshiki Nakajima
Jul 8, 2015·Saudi Journal of Biological Sciences·Marijana KosanićTatjana Stanojković
Mar 20, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Tarika ThumvijitRawiwan Wongpoomchai

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