PMID: 7334384Nov 1, 1981Paper

Anticancer indole alkaloids of Rhazya stricta

Journal of Natural Products
S MukhopadhyayG A Cordell

Abstract

The leaves and roots of Rhazya stricta (Apocynaceae) yielded four indole alkaloids. Three of these isolated, vallesiachotamine (1), sewarine (3) and tetrahydrosecamine (4), displayed cytotoxic activity; polyneuridine (2) was not reported previously from this species. Tetrahydrosecaminediol (5), its acetate 6, and didemethoxycarbonyl-tetrahydrosecamine (7) were prepared from tetrahydrosecamine (4) by chemical reactions. The diol 5 was highly cytotoxic.

Citations

Apr 6, 2012·Archives of Pharmacal Research·Paula R O SoaresLídia Andreu Guillo
Jul 8, 1994·Journal of Ethnopharmacology·I A WasfiA A Abdalla
Dec 4, 2013·Comptes rendus biologies·Jamal S M SabirAhmed Bahieldin
Dec 20, 2012·Journal of Asian Natural Products Research·Lu LiuSheng-Ping Xu
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·S ThenmozhiA K Mohanakrishnan
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·B GunasekaranV Manivannan
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·S ThenmozhiA K Mohanakrishnan
Jul 15, 2011·Acta Crystallographica. Section E, Structure Reports Online·Alagappa RammohanA K Mohana Krishnan
Jun 26, 2013·Acta Crystallographica. Section E, Structure Reports Online·Piskala Subburaman KannanA Subbiahpandi
Dec 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amir AkhgariHeiko Rischer
Feb 15, 2017·Chemistry Central Journal·Abdullah Y ObaidKulvinder Singh Saini
Dec 23, 2006·Phytotherapy Research : PTR·Syed Abdullah GilaniKazuo N Watanabe
May 29, 2020·Integrative Cancer Therapies·Nahid H HajrahKulvinder Singh Saini
Apr 26, 2014·Acta Crystallographica. Section E, Structure Reports Online·C RamathilagamV Manivannan
Apr 26, 2014·Acta Crystallographica. Section E, Structure Reports Online·J KanchanadeviV Manivannan
Nov 26, 2015·Acta Crystallographica. Section E, Crystallographic Communications·G VimalaA SubbiahPandi
May 19, 2018·Oncotarget·Raghupathy VengojiNicole A Shonka
Apr 7, 2015·Acta Crystallographica. Section E, Crystallographic Communications·R RajaA SubbiahPandi
Jul 1, 2017·BMC Complementary and Alternative Medicine·Faisal S AlagrafiMohammad A Wadaan
Jun 22, 2000·Phytotherapy Research : PTR·B H AliM O Tanira
Nov 26, 2015·Acta Crystallographica. Section E, Crystallographic Communications·M P SavithriA SubbiahPandi
May 14, 2005·Environmental Toxicology·Paul G Becher, Friedrich Jüttner
Jan 23, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Afrah E MohammedWalied M Alarif

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