Anticancer potential of rosmarinic acid and its improved production through biotechnological interventions and functional genomics

Applied Microbiology and Biotechnology
Mallappa Kumara SwamyAli Ghasemzadeh

Abstract

Rosmarinic acid (RA) is a highly valued natural phenolic compound that is very commonly found in plants of the families Lamiaceae and Boraginaceae, including Coleus blumei, Heliotropium foertherianum, Rosmarinus officinalis, Perilla frutescens, and Salvia officinalis. RA is also found in other members of higher plant families and in some fern and horned liverwort species. The biosynthesis of RA is catalyzed by the enzymes phenylalanine ammonia lyase and cytochrome P450-dependent hydroxylase using the amino acids tyrosine and phenylalanine. Chemically, RA can be produced via methods involving the esterification of 3,4-dihydroxyphenyllactic acid and caffeic acid. Some of the derivatives of RA include melitric acid, salvianolic acid, lithospermic acid, and yunnaneic acid. In plants, RA is known to have growth-promoting and defensive roles. Studies have elucidated the varied pharmacological potential of RA and its derived molecules, including anticancer, antiangiogenic, anti-inflammatory, antioxidant, and antimicrobial activities. The demand for RA is therefore, very high in the pharmaceutical industry, but this demand cannot be met by plants alone because RA content in plant organs is very low. Further, many plants that synthesize...Continue Reading

References

Jan 1, 1992·Critical Reviews in Food Science and Nutrition·F Shahidi, P K Wanasundara
Nov 21, 2001·Journal of Agricultural and Food Chemistry·W Zheng, S Y Wang
Dec 17, 2002·Phytochemistry·Maike Petersen, Monique S J Simmonds
Oct 8, 2003·Current Pharmaceutical Design·A FerrándezR W Burt
Jun 16, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C SanbongiT Yoshikawa
Jul 23, 2004·Biotechnology Letters·Milen GeorgievMladenka Ilieva
Sep 1, 2004·Trends in Plant Science·Kirsi-Marja Oksman-Caldentey, Dirk Inzé
Apr 11, 2006·British Journal of Pharmacology·Jongsung LeeYeong Shik Kim
May 30, 2006·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Milen GeorgievMladenka Ilieva
Jul 28, 2006·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Izabela GrzegorczykHalina Wysokińska
Jul 27, 2007·Biochemical Pharmacology·Jongsung LeeDeokhoon Park
Nov 8, 2007·Natural Product Research·Bektas Tepe, Atalay Sokmen
Aug 7, 2008·Biotechnology Advances·Adam Matkowski
Oct 18, 2008·Mutation Research·Michelle Andrade FurtadoDenise Crispim Tavares
Oct 1, 2007·Pakistan Journal of Biological Sciences : PJBS·Bernard FrançoiseNejad Fallah Zahra
Jun 3, 2009·Applied Microbiology and Biotechnology·Milen I GeorgievAlexandre Maciuk
Jun 30, 2009·Phytochemistry·Maike PetersenStefan Wolters
Oct 21, 2009·Toxicology Letters·Jarosław PaluszczakWanda Baer-Dubowska
Nov 3, 2010·Journal of Young Pharmacists : JYP·R JainA Tiwari
Apr 21, 2011·International Immunopharmacology·An-Hee JangCheung-Seog Park
Aug 16, 2011·Critical Reviews in Biotechnology·Victor P BulgakovSergey A Fedoreyev
Nov 2, 2011·Plant Signaling & Behavior·Akula Ramakrishna, Gokare Aswathanarayana Ravishankar
Dec 1, 2011·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Chezhiyan Anusuya, Shanmugam Manoharan
Jan 13, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Karthikkumar VenkatachalamNalini Namasivayam
Mar 2, 2012·Chemotherapy·Akram AstaniPaul Schnitzler
May 29, 2012·Journal of Agricultural and Food Chemistry·Pham Anh TuanSang Un Park
Mar 23, 2013·Current Cancer Drug Targets·Varinder SinghNeena Capalash

❮ Previous
Next ❯

Citations

Nov 16, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Faten TaramDaniel A Linseman
Nov 15, 2019·Molecular Biology Reports·Hong Ngoc Thuy PhamChristopher J Scarlett
Nov 19, 2019·Current Topics in Medicinal Chemistry·Panupong MahalapbutrThanyada Rungrotmongkol
Feb 20, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ilham TouissHicham Harnafi
Jun 3, 2021·Cells·Deepu PanditaHosam O Elansary
May 7, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yongguang HanXiaoke Zheng

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
transgenic
RNA-seq
PCR

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.