Anticancer Properties of Fenofibrate: A Repurposing Use

Journal of Cancer
Xin LianLu Cai

Abstract

Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little toxicity, fenofibrate is a drug of the fibrate class that plays an important role in lowering the levels of serum cholesterol and triglycerides while elevating the levels of high-density lipoproteins. Recently, several studies have implied that fenofibrate may exert anticancer effects via a variety of pathways involved in apoptosis, cell-cycle arrest, invasion, and migration. Given the great potential that fenofibrate may have anticancer effects, this review was to investigate all published works which directly or indirectly support the anticancer activity of fenofibrate. These studies provide evidence that fenofibrate exerted antitumor effects in several human cancer cell lines, such as breast, liver, glioma, prostate, pancreas, and lung cancer cell lines. Among these studies some have further confirmed the possibility and efficacy of fenofibrate anticancer in xenograft mouse models. In the last part of this review, ...Continue Reading

Citations

Feb 6, 2019·International Journal of Molecular Sciences·Anika Dutta, Neelam Sharma-Walia
Apr 10, 2019·Journal of Clinical Pharmacology·I-Hsun LiLi-Ting Kao
Feb 17, 2019·Archives of Pharmacal Research·Min-Kyue Shin, Jae-Ho Cheong
Sep 25, 2019·Seminars in Cancer Biology·Sadhna AggarwalSubash Chandra Gupta
Jan 9, 2021·Frontiers in Oncology·Anna Mukha, Anna Dubrovska
Jun 7, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bárbara CostaNuno Vale
Aug 14, 2021·European Journal of Medicinal Chemistry·Xin QiaoJing-Yuan Xu

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Methods Mentioned

BETA
zymography
xenograft
biopsy

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