Anticancer Properties of Graviola (Annona muricata ): A Comprehensive Mechanistic Review

Oxidative Medicine and Cellular Longevity
Islam RadyJean Christopher Chamcheu

Abstract

Graviola (Annona muricata) is a small deciduous tropical evergreen fruit tree, belonging to the Annonaceae family, and is widely grown and distributed in tropical and subtropical regions around the world. The aerial parts of graviola have several functions: the fruits have been widely used as food confectionaries, while several preparations, especially decoctions of the bark, fruits, leaves, pericarp, seeds, and roots, have been extensively used in traditional medicine to treat multiple ailments including cancers by local communities in tropical Africa and South America. The reported therapeutic benefits of graviola against various human tumors and disease agents in in vitro culture and preclinical animal model systems are typically tested for their ability to specifically target the disease, while exerting little or no effect on normal cell viability. Over 212 phytochemical ingredients have been reported in graviola extracts prepared from different plant parts. The specific bioactive constituents responsible for the major anticancer, antioxidant, anti-inflammatory, antimicrobial, and other health benefits of graviola include different classes of annonaceous acetogenins (metabolites and products of the polyketide pathway), alka...Continue Reading

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Citations

Dec 14, 2019·BMC Complementary and Alternative Medicine·Carl AmmourySandra Rizk
Jun 5, 2020·Integrative Cancer Therapies·Ghada A El TawiilHebatallah E Mohamed
Oct 30, 2019·The Journal of Pharmacy and Pharmacology·Wai-Jo Jocelin ChanJoanna E Harnett
May 6, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Olufunke Eunice Ola-DaviesAnofi Ashafa
Mar 20, 2021·Scientific Reports·Mohamed Gamal ShehataSobhy Ahmed El-Sohaimy

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Methods Mentioned

BETA
MDA
ELISA
column chromatography

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