Abstract
6,7-dehydroroyleanone (DHR) is a cytotoxic abietane present in the essential oil of Plectranthus madagascariensis. Different extraction parameters were tested, and its extraction optimization was accomplished with a Clevenger apparatus-based hydrodistillation. After isolation, its effect on microtubules, P-glycoprotein and caspases was assessed on several cell lines and the compound was coupled with hybrid nanoparticles. The results show that DHR does not interfere with microtubule formation, but evades the resistance mechanisms of P-glycoprotein. Strong activation of caspases-3 and -9 indicates that DHR is able to induce apoptosis by triggering the intrinsic cell death pathway. Moreover, the assembly of DHR with hybrid nanoparticles was able to potentiate the effect of DHR in cancer cells. DHR seems to be a promising starting material with anticancer properties to further be explored.
References
Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
May 1, 1989·Journal of Natural Products·L T JonathanN R Farnsworth
Jul 30, 2005·Cell Death and Differentiation·L F DíazA Stutzin
Nov 18, 2005·Journal of Ethnopharmacology·Catherine W LukhobaAlan J Paton
Apr 1, 2006·Journal of Chemotherapy·M PesicS Ruzdijic
Nov 8, 2008·Blood·Giuliana GobbiMarco Vitale
Jun 10, 2010·Nanomedicine·Xiaowei Dong, Russell J Mumper
Jul 11, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Celine Dejoye TanziFarid Chemat
Jan 18, 2014·Molecular Cancer Therapeutics·Eiman MukhtarHasan Mukhtar
Nov 13, 2014·PloS One·Sara EstévezFrancisco Estévez
Aug 19, 2015·Biotechnology Advances·Atanas G AtanasovHermann Stuppner
Dec 15, 2015·Current Pharmaceutical Design·Diogo LadeirasPatrícia Rijo
Dec 15, 2015·PloS One·Catarina Oliveira SilvaMaria Teresa Neves-Petersen
Apr 9, 2016·Journal of Ethnopharmacology·Mohamed E M SaeedThomas Efferth
Apr 15, 2016·Therapeutic Delivery·Catarina Oliveira SilvaCatarina Pinto Reis
May 1, 2016·European Journal of Medicinal Chemistry·Chien-Yu ChenChih-Shiang Chang
Oct 28, 2016·PloS One·Catarina Oliveira SilvaMaria Teresa Neves-Petersen
Citations
Feb 6, 2020·Biomolecules·Przemysław SitarekPatricia Rijo
May 28, 2020·International Journal of Molecular Sciences·Vera M S IscaAlfonso T García-Sosa
Jan 11, 2019·Pharmaceutics·Catarina Oliveira SilvaCatarina Reis
Jun 21, 2020·Pharmaceuticals·Tomasz ŚliwińskiPatrícia Rijo
Dec 29, 2020·Frontiers in Pharmacology·Catarina GarciaPatrícia Rijo
Dec 6, 2020·Journal of Ethnopharmacology·Isa Anina Lambrechts, Namrita Lall
May 1, 2021·Pharmaceuticals·Epole NtungwePatrícia Rijo