Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction

Future Medicinal Chemistry
Catarina GarciaPatrícia Rijo

Abstract

6,7-dehydroroyleanone (DHR) is a cytotoxic abietane present in the essential oil of Plectranthus madagascariensis. Different extraction parameters were tested, and its extraction optimization was accomplished with a Clevenger apparatus-based hydrodistillation. After isolation, its effect on microtubules, P-glycoprotein and caspases was assessed on several cell lines and the compound was coupled with hybrid nanoparticles. The results show that DHR does not interfere with microtubule formation, but evades the resistance mechanisms of P-glycoprotein. Strong activation of caspases-3 and -9 indicates that DHR is able to induce apoptosis by triggering the intrinsic cell death pathway. Moreover, the assembly of DHR with hybrid nanoparticles was able to potentiate the effect of DHR in cancer cells. DHR seems to be a promising starting material with anticancer properties to further be explored.

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Citations

May 28, 2020·International Journal of Molecular Sciences·Vera M S IscaAlfonso T García-Sosa
Jan 11, 2019·Pharmaceutics·Catarina Oliveira SilvaCatarina Reis
Jun 21, 2020·Pharmaceuticals·Tomasz ŚliwińskiPatrícia Rijo
Dec 29, 2020·Frontiers in Pharmacology·Catarina GarciaPatrícia Rijo
Dec 6, 2020·Journal of Ethnopharmacology·Isa Anina Lambrechts, Namrita Lall

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Methods Mentioned

BETA
dynamic light scattering
atomic force microscopy
AFM
flow cytometry
NMR

Software Mentioned

Prism
ChemStation
Flowing
Summit

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