Anticancer Supramolecular Hydrogel of D/L-Peptide with Enhanced Stability and Bioactivity

Journal of Biomedical Nanotechnology
Chunhua RenJianfeng Liu

Abstract

Supramolecular nanofibers based on D-amino acid-containing peptide self-assembly have attracted increased interest recently because of their superior biostability. However, the construction of nanostructures containing D-amino acids is still insufficient at present, and their application in biomedical fields should be further explored. Herein, we demonstrated that the aggregation property of hydrophobic anticancer tyroservaltide (YSV) could be decreased by introducing D-amino acids. Using such strategy, we fabricated a novel anticancer hydrogelator based on the D/L-peptide of NapGDFDFDYGYSV (D-YSV). Through a heating-cooling process, NapGDFDFDYGYSV self-assembled into a stable hydrogel, while its control peptide of NapGFFYGYSV (L-YSV) self-assembled into an unstable suspension. The nanofiber of D-YSV exhibited an excellent resistance to proteinase digestion comparing with that of L-YSV, and a better anticancer efficiency in vitro due to its improved cellular uptake. Moreover, D-YSV possessed good biocompatibility and showed a prominent tumour inhibition capacity in vivo via tail vein injection. Our study demonstrates a powerful strategy to reduce the aggregation property and construct supramolecular hydrogels of bioactive hydro...Continue Reading

Citations

Oct 2, 2020·Chemical Communications : Chem Comm·Qian WangJianfeng Liu
Mar 4, 2020·Acta Pharmacologica Sinica·Fan YangZhi-Yong Qian
Sep 12, 2019·Biomaterials Science·Qian WangJianfeng Liu
Dec 19, 2018·ACS Applied Materials & Interfaces·Li-Jun YangJianfeng Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.