Anticandidal activity of hetero-dinuclear copper(II) Mn(II) Schiff base and its potential action of the mechanism

World Journal of Microbiology & Biotechnology
Bekir Mustafa YoğurtçuFikrettin Şahin

Abstract

Invasive fungal infections are one of the major challenges especially for immunosuppressed patients since they are drug resistant and pathogen to patients. Therefore, developing new, efficient and nonresistant antifungal agents have been a primary focus of international research. In the current study, a novel Schiff base [hetero-dinuclear copper(II) Mn(II) complex] (SB) derivative was investigated for its anticandidal activity against Candida albicans and possible mechanisms inducing cell death. The results revealed that SB treatment induces apoptotic and necrotic pathways in C. albicans ATCC10231 strain. Intracellular reactive oxygen species production determined by 2',7'-dichlorofluorescein diacetate staining was triggered by SB and amphotericin B administrations in a dose-dependent manner. Gene expression analysis demonstrated that SB exposure resulted in regulation of critical development and stress related gene expressions. SB treatment directly upregulated expression of stress related genes, DDR48 and RIM101, while suppressed important cell signaling and antibiotic resistance acquiring related genes such as HSP90, ERG11 and EFG1. Furthermore, CaMCA1 mRNA levels were found to be significantly high in SB-treated yeast cells...Continue Reading

References

Nov 14, 1997·The Journal of Cell Biology·F MadeoK U Fröhlich
May 20, 1999·The Journal of Cell Biology·F MadeoK U Fröhlich
Aug 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C ViscoliF Meunier
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Andrew J PhillipsMark Ramsdale
Sep 9, 2004·Chemical Society Reviews·Pier Giorgio Cozzi
Feb 14, 2006·BMC Infectious Diseases·Matteo BassettiClaudio Viscoli
May 23, 2006·Current Medicinal Chemistry·Sandeep SundriyalRahul Jain
Jul 15, 2006·Diagnostic Microbiology and Infectious Disease·Mariceli Araujo Ribeiro, Claudete Rodrigues Paula
Sep 2, 2014·Journal of Applied Microbiology·J H HwangD G Lee
Jan 13, 2015·Journal of Pathogens·Moiz A AnsariSaif Hameed
Jun 1, 2015·Beni-Suef University Journal of Basic and Applied Sciences·Ahmed M Abu-Dief, Ibrahim M A Mohamed

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Citations

Jun 22, 2018·World Journal of Microbiology & Biotechnology·Jun-Nan ZhangXiang-Hong Meng

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Methods Mentioned

BETA
scanning electron microscopy
PCR
electrophoresis
flow cytometry
environmental stress

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