PMID: 2104933Jan 1, 1990Paper

Anticandidal properties of N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid oligopeptides

Journal of Medicinal Chemistry
R AndruszkiewiczE Borowski

Abstract

Tri-, tetra-, and pentapeptides containing N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), an inactivator of glucosamine 6-phosphate synthase of fungal origin (a key enzyme in the biosynthesis of macromolecular components of the fungal cell wall) have been synthesized and investigated as anticandidal agents. Structure-activity relationships of a series of peptides revealed that tripeptides were generally more active than the other peptides examined. In this study, the lysyl peptide, Lys-Nva-FMDP has been found to be the most active compound in the series.

Citations

Jun 5, 2002·Biochimica Et Biophysica Acta·Sławomir Milewski
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·S MilewskiE Borowski
Oct 20, 1998·Medical Mycology·S MilewskiE Borowski
Sep 17, 2008·Antimicrobial Agents and Chemotherapy·Roland WakiecSlawomir Milewski
Jun 25, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Andrzej S SkwareckiMaria J Milewska
Nov 23, 2017·Frontiers in Microbiology·Marta SchielmannSławomir Milewski
Jan 13, 2006·Yeast·Sławomir MilewskiJarosław Olchowy
Apr 1, 1993·FEMS Microbiology Letters·E ZboińskaP Kafarski
Jan 13, 2018·Journal of Peptide Science : an Official Publication of the European Peptide Society·Andrzej S SkwareckiSławomir Milewski
Jun 23, 2005·Journal of Enzyme Inhibition and Medicinal Chemistry·Ryszard AndruszkiewiczAleksandra Walkowiak
Dec 13, 2005·Journal of Enzyme Inhibition and Medicinal Chemistry·Aleksandra WalkowiakRyszard Andruszkiewicz
Jun 11, 2002·Medical Mycology·A M Janiak, S Milewski
Mar 27, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Ahmet KertmenSławomir Milewski
Oct 9, 2007·Bioorganic & Medicinal Chemistry Letters·Anna MelcerSławomir Milewski
Jul 22, 2020·Journal of Medicinal Chemistry·Wei LiuShengzheng Wang

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