Abstract
Tri-, tetra-, and pentapeptides containing N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), an inactivator of glucosamine 6-phosphate synthase of fungal origin (a key enzyme in the biosynthesis of macromolecular components of the fungal cell wall) have been synthesized and investigated as anticandidal agents. Structure-activity relationships of a series of peptides revealed that tripeptides were generally more active than the other peptides examined. In this study, the lysyl peptide, Lys-Nva-FMDP has been found to be the most active compound in the series.
Citations
Aug 5, 2000·Il Farmaco·E Borowski
Jun 5, 2002·Biochimica Et Biophysica Acta·Sławomir Milewski
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·S MilewskiE Borowski
Oct 20, 1998·Medical Mycology·S MilewskiE Borowski
Sep 17, 2008·Antimicrobial Agents and Chemotherapy·Roland WakiecSlawomir Milewski
Apr 9, 2009·Medical Mycology·Joaquín González-IbarraEverardo López-Romero
Jun 25, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Andrzej S SkwareckiMaria J Milewska
Nov 23, 2017·Frontiers in Microbiology·Marta SchielmannSławomir Milewski
Jan 13, 2006·Yeast·Sławomir MilewskiJarosław Olchowy
Apr 1, 1993·FEMS Microbiology Letters·E ZboińskaP Kafarski
Jan 13, 2018·Journal of Peptide Science : an Official Publication of the European Peptide Society·Andrzej S SkwareckiSławomir Milewski
Jun 23, 2005·Journal of Enzyme Inhibition and Medicinal Chemistry·Ryszard AndruszkiewiczAleksandra Walkowiak
Dec 13, 2005·Journal of Enzyme Inhibition and Medicinal Chemistry·Aleksandra WalkowiakRyszard Andruszkiewicz
Apr 1, 1992·Journal of Chemotherapy·L KasprzakE Borowski
Jun 11, 2002·Medical Mycology·A M Janiak, S Milewski
Jul 11, 1998·Microbiology·Henryk ChmaraEdward Borowski
May 17, 2001·Bioorganic & Medicinal Chemistry·D ZgódkaE Borowski
Mar 27, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Ahmet KertmenSławomir Milewski
Oct 9, 2007·Bioorganic & Medicinal Chemistry Letters·Anna MelcerSławomir Milewski
Jul 22, 2020·Journal of Medicinal Chemistry·Wei LiuShengzheng Wang