Anticarbohydrate antibodies as markers of inflammatory bowel disease in a Central European cohort

European Journal of Gastroenterology & Hepatology
Karin MalíckováMilan Lukás

Abstract

The study discusses the role of antichitobioside carbohydrate antibody (ACCA), antilaminaribioside carbohydrate antibodies (ALCA), and antimannobioside carbohydrate antibodies (AMCA) in Central European patients with inflammatory bowel disease (IBD). Twohundred and seventy-two serum samples were used - 116 Crohn's disease (CD), 84 ulcerative colitis, and 72 healthy control samples. All samples were evaluated using enzyme-linked immunosorbent assay for the following four anticarbohydrate assays: ACCA, ALCA, AMCA, and anti-Saccharomyces cerevisiae antibodies (gASCA). gASCA antibodies showed the highest sensitivity (67%) for a CD diagnosis, followed by AMCA (31%), ACCA (27%), and ALCA (25%). Positivity of at least one of the four assays increased the overall sensitivity of antibody testing in CD up to 85.5%. Mean serum gASCA levels were significantly higher in CD patients who were younger at diagnosis and had a longer disease duration before blood sampling (P<0.001). In nonstricturing, nonpenetrating CD, serum gASCA levels were lower than in patients with stricturing and/or penetrating behavior (P<0.05). The strongest association of gASCA was found with ileocolonic CD and with upper gastrointestinal disease (P<0.001). No associati...Continue Reading

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Citations

Nov 10, 2011·Inflammatory Bowel Diseases·Lani PrideauxMichael A Kamm
Mar 13, 2012·World Journal of Gastroenterology : WJG·Eduardo Garcia VilelaAloísio Sales da Cunha
May 8, 2014·World Journal of Gastroenterology : WJG·Márta KovácsGábor Veres
Jun 13, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Radu M Nanau, Manuela G Neuman
Jun 23, 2012·Digestive Diseases·László Herszényi, Zsolt Tulassay
Jul 28, 2020·Nature Reviews. Gastroenterology & Hepatology·Matthew R KudelkaAndrew S Neish

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