Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum.

Journal of Natural Medicines
Toru YaguraHoyoku Nishino

Abstract

An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

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Citations

Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Asghar AbbasAurangzeb Hasan
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Asghar AbbasAurangzeb Hasan
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Feb 19, 2013·BMC Complementary and Alternative Medicine·Ivana Z MatićZorica D Juranić
May 22, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·En-Hui ZhangBin Liu
Jan 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ji-Hye SeoSeung-Sik Cho
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Mar 4, 2015·Biotechnology Advances·Rakshit K DevappaRobert F H Dekker
Jul 8, 2015·Journal of Natural Products·Robert BrkljačaSylvia Urban
Dec 17, 2014·Nutrition and Cancer·Irfan Ahmad Mir, Ashu Bhan Tiku
Apr 20, 2021·Frontiers in Plant Science·Nadja FörsterInga Mewis
Aug 28, 2021·Biomolecules·Hiba A JasimSatyajit D Sarker

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