Abstract
Infants born from mothers with antiphospholipid antibody (aPL) -positive autoimmune disease were prospectively evaluated for anticardiolipin and anti-beta2 glycoprotein I antibodies (group 1) and for growth and neurological development. The results were compared with those obtained from two age-matched control groups (group 2 and 3). All infants were negative for anticardiolipin at 12 months of life, whereas 14 (63.6%), eight (33.3%), and 10 (55.5%) of infants from group 1, 2, and 3, respectively, were positive for anti-beta2 glycoprotein I. At follow-up, all infants had normal growth and neurological development. No thrombotic complication was observed. The negativity of anticardiolipin in all infants at 12 months suggests that anticardiolipin detection is the best assay to evaluate the disappearance of maternal aPL and to estimate the potential risk of thrombosis associated with these antibodies. The high rate of anti-beta2 glycoprotein I positivity in all three groups of infants may indicate that the synthesis of this antibody is stimulated by aspecific factors.
Citations
Aug 14, 2008·Current Opinion in Rheumatology·Tadej Avcin
May 17, 2012·Annals of the Rheumatic Diseases·Arsene MekinianMarie-Claire Boffa
Nov 1, 2006·Women's Health·Sonia ZattiAngela Tincani
Jan 28, 2009·Current Rheumatology Reports·Angela TincaniMario Motta
Oct 29, 2015·Immunologic Research·Czeslawa KowalBetty Diamond
Jul 18, 2015·Journal of Immunology Research·Christoph FickentscherMartin Herrmann
Apr 10, 2015·Current Rheumatology Reports·Cassyanne L AguiarBarry L Myones
Apr 11, 2017·Lupus·C NalliA Tincani
Sep 22, 2009·Early Human Development·Mario MottaGaetano Chirico
Mar 12, 2017·Blood Cells, Molecules & Diseases·Dax G RumseyPatti Massicotte
Sep 18, 2014·Lupus·C NalliA Tincani
Apr 26, 2014·Lupus·C NalliA Tincani
Aug 13, 2009·Lupus·M-C BoffaA Tincani
Aug 23, 2007·Lupus·T Avcin, E D Silverman
Aug 23, 2007·Lupus·M-C Boffa, E Lachassinne
Mar 4, 2008·Arthritis and Rheumatism·R NacinovichA Tincani
Aug 6, 2020·Lupus·Viktoria BitsadzeAlexander Makatsariya
Jun 24, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jae-Kyoon HwangHyun Ju Lee
Mar 4, 2020·Current Rheumatology Reports·Arzu Soybilgic, Tadej Avcin
Jan 5, 2021·Frontiers in Pharmacology·Maria-Grazia LazzaroniAngela Tincani
Dec 18, 2020·Frontiers in Pediatrics·Teresa GianiRolando Cimaz
Jun 5, 2021·Lupus·Georges El HasbaniImad Uthman