Anticardiolipin antibodies and mortality in patients with ischemic stroke: a prospective follow-up study

Neuroepidemiology
D TanneS R Levine

Abstract

The purpose of the present prospective observational study was to assess whether or not the presence of anticardiolipin antibodies (aCL) in unselected first ischemic stroke patients is associated with adverse outcome. Consecutive patients (n = 300; mean age 64 years; 48% males) presenting with a first acute ischemic stroke were evaluated for IgG aCL and were systematically followed up. During a median follow-up of 21 months, 58 patients (19%) died. Mortality rates were higher in patients with aCL >20 IgG phospholipid units (GPL) [33 vs. 18%; relative risk (RR) 1.94, 95% confidence interval (CI) 1.02-3.67; p = 0.042] or >40 GPL (40 vs. 19%; RR 2.46, 95% CI 1.05-5.75; p = 0.037). Elevated aCL did not confer an increased risk during follow-up of a combined end point of stroke, myocardial infarction and vascular death or of nonfatal thrombo-occlusive events. Rates of malignancy detected during follow-up were higher among patients with aCL >20 GPL (19 vs. 5%, p = 0.007) and >40 GPL (27 vs. 6%, p = 0.01). The excess mortality associated with elevated aCL was eliminated after adjustment for age, cardiovascular risk factors and malignancy. These results demonstrate that aCL above 20-40 GPL among consecutive ischemic stroke patients is ...Continue Reading

Citations

Oct 6, 2005·Journal of Thrombosis and Thrombolysis·Robin L Brey
Jun 10, 2003·Current Atherosclerosis Reports·Cheryl Bushnell, Larry B Goldstein
Jul 27, 2001·Current Rheumatology Reports·D Tanne, S Hassin-Baer
Dec 24, 2002·Current Opinion in Rheumatology·Eliza Chakravarty, Mark C Genovese
Jun 6, 2009·Stroke; a Journal of Cerebral Circulation·Kumar RajamaniUNKNOWN PICSS-APASS Investigators
Aug 15, 2003·Southern Medical Journal·Marc J Kahn
Feb 25, 2014·Experimental Neurology·Meaghan Roy-O'Reilly, Louise D McCullough
Jun 22, 2006·Cerebrovascular Diseases·Li-Ming LienChyi-Huey Bai
Feb 5, 2004·Current Cardiology Reports·Stanley Tuhrim
Jan 22, 2008·Hematology/oncology Clinics of North America·Rima M Dafer, José Biller
May 9, 2009·Journal of Thrombosis and Haemostasis : JTH·S SaidiW Y Almawi
Jan 5, 2011·Clinical & Developmental Immunology·Hirohisa OkumaShigeharu Takagi
Dec 6, 2005·Immunobiology·Wolfgang MiesbachInge Scharrer
Jan 18, 2006·Clinical Neurology and Neurosurgery·Wolfgang MiesbachInge Scharrer
Dec 23, 2014·International Journal of Rheumatic Diseases·Yosra CherifZouhir Bahloul
Oct 11, 2014·Circulation·Zoe ArvanitakisSteven R Levine
May 3, 2014·Stroke; a Journal of Cerebral Circulation·Walter N KernanUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
Mar 17, 2009·Stroke; a Journal of Cerebral Circulation·William WhiteleyPeter Sandercock
Dec 4, 2010·Stroke; a Journal of Cerebral Circulation·Larry B GoldsteinUNKNOWN Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research
Sep 13, 2005·CNS Spectrums·Steven R Levine
Sep 14, 2017·Cardiovascular Research·Rosebella A IsemeMichael Boyle
Jun 7, 2007·Archives of Pathology & Laboratory Medicine·Aliyah Rahemtullah, Elizabeth M Van Cott
Nov 4, 2021·World Neurosurgery·Sauson SoldozyM Yashar S Kalani
Nov 21, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Wookjin YangSeung-Hoon Lee

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