PMID: 8602297Apr 1, 1996Paper

Anticardiolipin antibodies: clinical consequences of "low titers"

Obstetrics and Gynecology
R M SilverD W Branch

Abstract

To clarify the implications of low levels of immunoglobulin (Ig)-G or IgM anticardiolipin antibodies. Women who underwent clinically indicated testing for antiphospholipid antibodies were divided into four groups based on results: 1) high-positive (lupus anticoagulant or more than 19 IgG binding units of anticardiolipin antibodies; N = 131), 2) low-positive IgG (fewer than 20 IgG binding units; N 93), 3) IgM only (more than nine IgM binding units; N 97), and 4) negative (N = 153). The development of antiphospholipid antibody-related disorders was assessed for the time interval from initial antibody testing to patient interview. The median study interval for each group was at least 4 years. Forty-five percent of women had repeat testing at the time of interview. Women in the high-positive group were more likely to develop at least one new medical complication than those in the low-positive IgG (odds ratio [OR] 4.49, 95% confidence interval [CI] 2.01-10.03), IgM only (OR 6.00, 95% CI 2.65-13.59), and negative (OR 9.11, 95% CI 3.92-21.2) groups. In contrast, the low-positive IgG, IgM only, and negative groups had similar risks for the development of new disorders. Twelve of 129 (9.3%) women in the low-positive IgG, IgM only, or ne...Continue Reading

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Citations

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Jul 1, 1997·American Journal of Obstetrics and Gynecology·R M SilverD W Branch

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