Anticardiolipin antibodies in children and adolescents with insulin-dependent diabetes mellitus

European Journal of Pediatrics
R LoriniF Severi

Abstract

Anticardiolipin antibodies were determined in 29 diabetic children and adolescents, aged 3.9-26.8 years, with disease duration from 1 month to 19 years. Anti-islet cell antibodies (ICA-IgG and CF-ICA), anti-insulin antibodies (IAA), antithyroid antibodies and non organ-specific (NOSA) antibodies were also determined. Patients were grouped according to insulin-dependent diabetes mellitus (IDDM) duration: group I (n = 11) < 6 months, and group II (n = 18) > 5 years. Eleven of group II patients showed precocious signs of micro-angiopathic complications. Forty-two age- and sex-matched healthy subjects served as controls. IgG and IgM anticardiolipin antibodies were evaluated by ELISA and their results expressed as arbitrary units (AU). IgG anticardiolipin antibodies were found in 7 patients (24%), while IgM anticardiolipin antibodies were absent in all. IgG anticardiolipin antibodies were more frequent in IDDM patients than in controls (P < 0.005) and group I (in 6 out of 11 patients; 54.5%) than in group II (in 1 out of 18 patients; 5.5%) (P < 0.025). In five out of six group I patients with IgG anticardiolipin antibodies, ICA-IgG and/or CF-ICA were also found. No correlation was observed between anticardiolipin and other auto-anti...Continue Reading

References

Oct 30, 1999·Clinical and Experimental Immunology·P GargiuloJ A McIntyre
Sep 5, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Henri GinLilly Maneta-Peyret
May 2, 2015·BMJ Open Diabetes Research & Care·William B HortonAngela R Subauste
Aug 2, 2006·Rheumatic Diseases Clinics of North America·Rolando Cimaz, Elodie Descloux
Aug 1, 1997·Rheumatic Diseases Clinics of North America·A Ravelli, A Martini
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B Samstein, J L Platt
Jun 27, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·G d'AnnunzioR Lorini
Dec 24, 1997·Journal of Pediatric Endocrinology & Metabolism : JPEM·F Presotto, C Betterle
Jun 10, 2000·Alimentary Pharmacology & Therapeutics·D GuiA Albanese

Citations

Sep 1, 1992·Annals of the Rheumatic Diseases·B SerioloS Accardo
Feb 1, 1992·Annals of the Rheumatic Diseases·R A Asherson, R Cervera
Sep 1, 1991·Annals of the Rheumatic Diseases·R CaporaliA Martini
Jan 1, 1991·Autoimmunity·A A RossiniJ P Mordes
Oct 1, 1990·Seminars in Arthritis and Rheumatism·L R SammaritanoM D Lockshin
Jan 1, 1989·Autoimmunity·D LarizzaF Severi
Aug 1, 1986·European Journal of Pediatrics·R LoriniF Severi
Jan 1, 1993·Diabetes Research and Clinical Practice·R LoriniF Severi
Aug 7, 1993·Lancet·G R Hughes

Related Concepts

Anticardiolipin Antibody Measurement
Cystic Fibrosis
Teens
Islet Cell
Insulin Antibody Measurement
Diabetes Mellitus, Insulin-Dependent
HLA Typing
Diabetes, Autoimmune
Islets of Langerhans
Diabetes Mellitus

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