PMID: 1577600Mar 1, 1992

Anticardiolipin antibodies in cutaneous lupus erythematosus. Incidence and importance as a marker of vascular symptoms

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
B Tebbe, C E Orfanos

Abstract

In 67 patients with lupus erythematosus (LE), 33 patients with the chronic discoid type (CDLE), 22 with the subacute cutaneous type (SCLE) and 12 with systemic LE (SLE), the presence of circulating anticardiolipin antibodies (ACA) of the IgG and IgM isotypes was investigated with an enzyme immunoassay (ELISA). ACA of the IgG isotype were found in 13 patients (= 39.4%) with CDLE and ACA-IgM in 5 other cases (= 15.2%); among the SCLE patients ACA-IgG was increased in 8 (= 36.4%) and ACA-IgM in 1 other (= 4.5%), while in 3 further patients (= 13.6%) both ACA-IgG and IgM were detected. In total, ACA were found in 54.6% of the CDLE and in 54.5% of the SCLE patients. In SLE ACA-IgG alone was seen in 41.7% of the patients and ACA of both isotypes in another 33.3%. The serum levels of ACA were higher in SLE than in the cutaneous LE subsets. No correlation with the presence of ANA and binding capacity was detected in any of these groups. Vascular symptoms were seen in 19 of 39 patients with detectable ACA (= 48.7%), whereas only 9 of 27 ACA-negative patients (= 33.3%) were found to have vascular symptoms on clinical examination. Only 1 of the patients with isolated ACA-IgM elevation (5 CDLE patients, 1 SCLE patient) had vascular symptom...Continue Reading

Related Concepts

Autoantibodies
Diphosphatidylglycerols
Polyglobin
IgM2
Lupus Erythematosus, Subacute Cutaneous
Lupus Erythematosus, Discoid
Lupus Erythematosus, Systemic
Raynaud Phenomenon
Vasculitis
Antiphospholipid Syndrome

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