PMID: 8964598Jan 1, 1996Paper

Anticardiolipin, but not the 16/6 Id anti-DNA antibody induces pregnancy failure

Immunology Letters
Z SthoegerE Mozes

Abstract

The primary antiphospholipid syndrome or the antiphospholipid syndrome in systemic lupus erythematosus patients (defined as secondary antiphospholipid syndrome) are characterized by the presence of thrombosis, thrombocytopenia and recurrent fetal loss in association with anticardiolipin antibodies. To determine the causal role of these antibodies in the pathogenesis of pregnancy failure we studied the effects of immunization with monoclonal anti-DNA antibody (designated 16/6 Id; no cardiolipin reactivity) and anticardiolipin monoclonal antibody (designated 2C4C2; binds DNA as well) on the outcome of allogeneic pregnancies in BALB/c mice. Mating of BALB/c females 4 weeks after active immunization with the 16/6 Id, anti-DNA monoclonal antibody resulted in normal pregnancy outcome, similar to control mouse groups. In contrast to that, immunization with the 2C4C2 anticardiolipin antibodies resulted in severe gestational failure with low pregnancy rate, low numbers of fetuses and high rates of resorptions. The fertility index of those mice was extremely low as compared to the 16/6 Id-immunized mice or the control groups. Furthermore, a correlation was shown between the presence of anticardiolipin antibody levels in the sera of the m...Continue Reading

References

Feb 1, 1992·Annals of the Rheumatic Diseases·J L ViannaG R Hughes
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M BlankY Shoenfeld
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S MendlovicE Mozes
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Z M SthoegerB Tartakovsky

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Citations

Nov 14, 1998·Lupus·M D Lockshin

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.