PMID: 6337593Jan 1, 1983Paper

Anticentromere antibody. Clinical Correlations and association with favorable prognosis in patients with scleroderma variants

Arthritis and Rheumatism
G A McCartyF A Barada

Abstract

The presence of antibody to the chromosomal centromere appears to be associated with a subset of patients with the limited CREST form of scleroderma. To further define the prognostic value of this autoantibody, 27 patients, who were identified as having anticentromere antibody by screening antinuclear antibody tests using HEp-2 cell substrates, were followed clinically and serologically for 2 years. The presence of anticentromere antibody is common in the limited CREST forms of systemic sclerosis, and it is often the only autoantibody specificity present in the sera of patients with the CREST variant. When compared with other patients who exhibit speckled or nucleolar antinuclear antibody patterns, those with anticentromere antibody had significantly less major organ system involvement.

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Related Concepts

Fluorescent Antinuclear Antibodies
Tumoral Calcinosis
Centromere
Chromosomes
Esophageal Diseases
Immunofluorescence Assay
Raynaud Phenomenon
Systemic Scleroderma
Spider Veins

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