Antichlamydial sterol from the Red Sea sponge Callyspongia aff. implexa

Planta medica
Usama Ramadan AbdelmohsenSafwat A Ahmed

Abstract

Marine sponges are rich sources of natural products exhibiting diverse biological activities. Bioactivity-guided fractionation of the Red Sea sponge Callyspongia aff. implexa led to the isolation of two new compounds, 26,27-bisnorcholest-5,16-dien-23-yn-3β,7α-diol, gelliusterol E (1) and C27-polyacetylene, callimplexen A (2), in addition to the known compound β-sitosterol (3). The structures of the isolated compounds were determined by 1D- and 2D-NMR techniques as well as high-resolution tandem mass spectrometry and by comparison to the literature. The three compounds (1-3) were tested against Chlamydia trachomatis, an obligate intracellular gram-negative bacterium, which is the leading cause of ocular and genital infections worldwide. Only gelliusterol E (1) inhibited the formation and growth of chlamydial inclusions in a dose-dependent manner with an IC50 value of 2.3 µM.

Citations

Jan 10, 2017·Marine Drugs·Huawei ZhangPhillip Crews
Aug 8, 2019·Phytochemical Analysis : PCA·Omnia Hesham AbdelhafezUsama Ramadan Abdelmohsen
Sep 10, 2020·Marine Drugs·Ebaa M El-HossaryUsama Ramadan Abdelmohsen
Mar 16, 2017·Natural Product Reports·John W BluntMichèle R Prinsep
Sep 30, 2020·Chemistry : a European Journal·Kwang-Yoon KoMargaret A Brimble
Apr 2, 2021·BioMed Research International·Min NiXiaofeng Bao

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