Anticholinergic and sedative medications exposure in older patients: a cross-sectional study

International Journal of Clinical Pharmacy
Xiaolin ZhangXinmin Liu

Abstract

Background The Drug Burden Index is a risk assessment tool used to quantify anticholinergic and sedative medications burden of older patients. There have been no previously published reports the exposure of anticholinergic and sedative medications in China. Objective We investigated the prevalence and correlates risk factors of anticholinergic and sedative medications in hospitalized older patients with polypharmacy in China. Settings The Department of Geriatrics in a tertiary care teaching hospital. Methods A retrospective analysis of patient medical records of hospitalized older patients with polypharmacy was undertaken at a large university teaching hospital in China. Polypharmacy was defined as the regular use of more than five medications. Prescribing of anticholinergic and sedative medications was identified using the medication list of the Drug Burden Index, and logistic regression analysis determined associations between drug exposure and independent variables. Main outcome measure Anticholinergic and sedative medications identified by the Drug Burden Index. Results A total of 383 patients were included in this study, with an average age of 82.6 ± 7.0 years and included 72.9% (279/383) male patients. Of the study partic...Continue Reading

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Citations

Feb 16, 2021·Frontiers in Pharmacology·Joseph O FadareTosin A Agbesanwa
Jul 27, 2021·Current Epidemiology Reports·Heather E Barry, Carmel M Hughes

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