Anticholinergic burden measures and older people's falls risk: a systematic prognostic review.

Therapeutic Advances in Drug Safety
Carrie StewartPhyo K Myint

Abstract

Several adverse outcomes have been associated with anticholinergic burden (ACB), and these risks increase with age. Several approaches to measuring this burden are available but, to date, no comparison of their prognostic abilities has been conducted. This PROSPERO-registered systematic review (CRD42019115918) compared the evidence behind ACB measures in relation to their ability to predict risk of falling in older people. Medline (OVID), EMBASE (OVID), CINAHL (EMBSCO) and PsycINFO (OVID) were searched using comprehensive search terms and a validated search filter for prognostic studies. Inclusion criteria included: participants aged 65 years and older, use of one or more ACB measure(s) as a prognostic factor, cohort or case-control in design, and reporting falls as an outcome. Risk of bias was assessed using the Quality in Prognosis Studies (QUIPS) tool. Eight studies reporting temporal associations between ACB and falls were included. All studies were rated high risk of bias in ⩾1 QUIPS tool categories, with five rated high risk ⩾3 categories. All studies (274,647 participants) showed some degree of association between anticholinergic score and increased risk of falls. Findings were most significant with moderate to high leve...Continue Reading

References

Mar 11, 2011·Dementia and Geriatric Cognitive Disorders·Gobhathai SittironnaritUNKNOWN AIBL research group
Oct 12, 2013·Basic & Clinical Pharmacology & Toxicology·Hege Kersten, Torgeir Bruun Wyller
Oct 6, 2014·Journal of the American Medical Directors Association·Francesco LandiAntonio Cherubini
Jul 23, 2015·Journal of the American Geriatrics Society·Kathryn RichardsonRose Anne Kenny
Feb 6, 2018·Journal of the American Medical Directors Association·Max de VriesUNKNOWN EUGMS Task and Finish Group on Fall-Risk-Increasing Drugs
Jul 28, 2020·Journal of the American Medical Directors Association·Carrie StewartPhyo Kyaw Myint
Oct 24, 2020·Drugs & Aging·Jonas ReinoldFederica Edith Pisa

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Software Mentioned

Excel
PsycInfo
Comprehensive Meta - Analysis
Quality in Prognosis Studies ( QUIPS )

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