Anticholinergic drugs in overactive bladder

Gynécologie, obstétrique & fertilité
J Muhlstein, B Deval

Abstract

The overactive bladder syndrome (OAB) associates urgency, frequency, nycturia, more or less associated with urinary incontinence. Its frequency is between 16 to 45 %, in the general population; the number of affected people in the USA being estimated at 34 million. Symptomatology is primarily marked by the abrupt, irrepressible need to urinate, impossible to defer, but also by a diurnal and night high mictional frequency. This OAB is more frequent when patients age increases, and affects indifferently men and women. The OAB induces a known negative impact on the quality of life and can lead to depression, sexual disorders, sleep disorders and a professional absenteism. The OAB medical treatment is actively concerned by the research since the discovery of oxybutinine. Tolterodin, solifenacin, darifenacin, trospium chloride supplement the therapeutic arsenal. New formulations (immediate and extended releases), new administration mediums (intravesical, transdermic, vaginal, rectal), new active ingredients (botulinic toxin, capsaicine, resiniferatoxine) are currently tested. The therapeutic options multiply, aiming at reducing to the maximum symptomatology, as well as the induced side effects.

References

Oct 30, 1999·International Urogynecology Journal and Pelvic Floor Dysfunction·H P DrutzS Radomski
Dec 15, 2000·Urology·R R Dmochowski, R A Appell
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May 6, 2004·The Journal of Urology·Norman ZinnerUNKNOWN Trospium Study Group
Jul 23, 2004·Physiological Reviews·Karl-Erik Andersson, Anders Arner
Aug 17, 2006·BJU International·Christopher R Chapple, E Ann Gormley

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Citations

Oct 14, 2011·American Journal of Physiology. Renal Physiology·Serge A Y AfeliGeorgi V Petkov
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderUNKNOWN CGTP Collaborators
May 9, 2019·Revista da Associação Médica Brasileira·Carlos Alberto Ricetto SacomaniWanderley M Bernardo

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