Anticholinergic load negatively correlates with recovery of cognitive activities of daily living for geriatric patients after stroke in the convalescent stage

Journal of Clinical Pharmacy and Therapeutics
E KoseT Hamamoto

Abstract

Anticholinergic drugs are associated with risks of falls, confusion and cognitive dysfunction. However, the effect of anticholinergic drug use on rehabilitation outcomes after a stroke is poorly documented. We therefore aimed to establish whether the anticholinergic load was associated with functional recovery among geriatric patients convalescing after stroke. Consecutive geriatric stroke patients admitted and discharged from a convalescence rehabilitation ward between 2010 and 2016 were included in this retrospective cohort study. Anticholinergic load was assessed by the Anticholinergic Risk Scale (ARS), and functional recovery was assessed by the Functional Independence Measure (FIM). The primary outcome was cognitive FIM (FIM-C) gain, but we also assessed the interaction of other putative factors identified from univariate analysis. Multivariate analyses were performed, adjusting for confounding factors. We included 418 participants (171 males, 247 females) with a median age of 78 years (interquartile range, 72-84 years). Multiple regression analysis revealed that ARS change, length of stay, and epilepsy were independently and negatively correlated with cognitive FIM gain. Multiple logistic regression analysis indicated tha...Continue Reading

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Citations

Jul 22, 2020·Geriatrics & Gerontology International·Eiji Kose, Hidetaka Wakabayashi
Aug 23, 2018·International Journal of Clinical Pharmacy·Eiji KoseToshiichi Seki
Dec 24, 2019·Frontiers in Neuroscience·Jorge López-ÁlvarezLuis Agüera-Ortiz
Oct 5, 2020·European Journal of Clinical Pharmacology·Angela LisibachMonika Lutters
Apr 14, 2021·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Susmita ChandramouleeshwaranTarek K Rajji

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