Anticholinergics do not affect the sexual function in women diagnosed with multiple sclerosis

Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
J Di MarcoG Amarenco

Abstract

Determine if the initiation of an anticholinergic treatment affects the sexual function in women diagnosed with multiple sclerosis (MS). It was a single-centre prospective open label study on 18 women affected by MS, with a clinical overactive bladder syndrome, and examined before and after anticholinergic treatment. Several variables were studied before and after treatment: the total anticholinergic load (Anticholinergic Drug Scale [ADS]), the Female Sexual Function Index, the Urinary Symptom Profile (USP) and functional status (EDSS, MIF). Quantitative variables were analyzed using Student's test. Eighteen women with an average age of 48.3 years old (±10.7 years), average EDSS of 4.6 (±1.5) were examined before and after anticholinergic treatment (solifenacin and trospium). Anticholinergic load at baseline was 0.33 (±0.5) and 3.44 (±0.70) after treatment (P<0.0001). The initiation of an anticholinergic treatment allowed a significant improvement on the subscore OAB USP (10.25±4.3 to 6.22±3 P=0.01). No significant impacts of the anticholinergic load on the Female Sexual Function Index (FSFI) score (18.9±10.8 to 21.2±10.8 P=0.06) and sub-items lubrification (3.6±2.2 to 3.7±2.2 P=0.6), pain (3.6±2.5 to 4.2±2.3 P=0.4), desire (3±...Continue Reading

References

Jan 1, 1981·International Rehabilitation Medicine·P O Lundberg
Sep 28, 2000·The New England Journal of Medicine·J H NoseworthyB G Weinshenker
Jul 7, 2001·Journal of the Neurological Sciences·M ZorzonG Cazzato
Jan 25, 2003·Journal of Sex Research·Marita P McCabe
May 11, 2006·Journal of Clinical Nursing·Jeannine Marguerite ChristophersonKenneth G Warren
Jul 7, 2007·Multiple Sclerosis : Clinical and Laboratory Research·Yaprak SeçilCumhur Ertekin
Aug 20, 2008·Multiple Sclerosis : Clinical and Laboratory Research·Vassilios TzortzisMichael D Melekos
Feb 10, 2009·Nature Clinical Practice. Urology·Sophie G FletcherElliot M Frohman
May 25, 2013·Sexuality and Disability·M Lew-Starowicz, R Rola
Dec 5, 2013·The Journal of Sexual Medicine·Haluk GumusHalim Yilmaz
Mar 4, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Sophie WylomanskiGaëlle Quéreux

❮ Previous
Next ❯

Citations

Oct 5, 2016·Neurourology and Urodynamics·Pawel MiotlaTomasz Rechberger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Impotence Research
G AslanA Esen
Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
Z KamalakH Kafalı
Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
M Thomas-PohlG Amarenco
© 2021 Meta ULC. All rights reserved