PMID: 9663700Jul 15, 1998Paper

Anticholinesterase activity of the fluorescent zoanthid pigment, parazoanthoxanthin A

Toxicon : Official Journal of the International Society on Toxinology
K SepcićP Macek

Abstract

A synthetic linear tetrazacyclopent(f)azulene compound, parazoanthoxanthin A (m.w. 214.2), strongly fluorescent pigment occurring in zoanthids, was characterized and assayed for anticholinesterase activity. The pigment, emitting fluorescence at lambda(em) 420 nm, was found to be a pure competitive inhibitor of cholinesterases. At pH 8.0, a Ki value of 19 and 26 microM was determined with insect recombinant, and electric eel acetylcholinesterase. Horse serum butyrylcholinesterase was less sensitive with a Ki of 70 microM.

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Citations

Aug 23, 2001·Archives of Biochemistry and Biophysics·L PasicN Poklar
Mar 17, 2010·Chemico-biological Interactions·Klara Bulc RozmanDusan Suput
Jan 27, 2017·Natural Product Reports·Romain Duval, Christophe Duplais
Mar 1, 2008·Angewandte Chemie·Douglas C BehennaBrian M Stoltz
Mar 30, 2019·Natural Product Reports·Lindon W K MoodieJohan Svenson
Oct 19, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·José M MonserratAdalto Bianchini

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