Anticholinesterase toxicity and oxidative stress

TheScientificWorldJournal
Dejan MilatovicMichael Aschner

Abstract

Anticholinesterase compounds, organophosphates (OPs) and carbamates (CMs) are commonly used for a variety of purposes in agriculture and in human and veterinary medicine. They exert their toxicity in mammalian system primarily by virtue of acetylcholinesterase (AChE) inhibition at the synapses and neuromuscular junctions, leading into the signs of hypercholinergic preponderance. However, the mechanism(s) involved in brain/muscle damage appear to be linked with alteration in antioxidant and the scavenging system leading to free radical-mediated injury. OPs and CMs cause excessive formation of F2-isoprostanes and F4-neuroprostanes, in vivo biomarkers of lipid peroxidation and generation of reactive oxygen species (ROS), and of citrulline, a marker of NO/NOS and reactive nitrogen species (RNS) generation. In addition, during the course of these excitatory processes and inhibition of AChE, a high rate of ATP consumption, coupled with the inhibition of oxidative phosphorylation, compromise the cell's ability to maintain its energy levels and excessive amounts of ROS and RNS may be generated. Pretreatment with N-methyl D-aspartate (NMDA) receptor antagonist memantine, in combination with atropine sulfate, provides significant protect...Continue Reading

Citations

May 22, 2007·Neurotoxicity Research·Samira S ValvassoriJoão Quevedo
Sep 5, 2007·Cell Biology and Toxicology·Mehmet Emin BuyukokurogluAdem Aslan
May 22, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Antonio F HernándezRaquel Alarcón
Jul 5, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Faith C H LiAlice Y W Chang
Dec 4, 2010·Environmental Health Perspectives·Brenda EskenaziNina Holland
Jan 23, 2009·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Beatrice A Golomb, Marcella A Evans
Jun 1, 2012·Pakistan Journal of Biological Sciences : PJBS·Siti Balkis BudinIzatus Shima Taib
Jan 6, 2010·Environmental Health Perspectives·Nicole M GattoBeate Ritz
Jan 24, 2014·TheScientificWorldJournal·Amin JazayeriSattar Ostadhadi
Jan 18, 2014·Occupational and Environmental Medicine·Anthony WangBeate Ritz
Jul 24, 2013·BioMed Research International·Ebru YıldırımNurgül Atmaca
Aug 26, 2014·Neural Computation·Beatrice A GolombJanis B Ritchie
Jun 16, 2012·Neurochemical Research·Neetu SainiRajat Sandhir
Aug 28, 2013·Neurochemical Research·Maha A E AhmedEngy M El-Morsy
Oct 16, 2009·Drug and Chemical Toxicology·Sibel Ozden, Buket Alpertunga
Jan 1, 2007·Toxicology Mechanisms and Methods·Nasim AmirkabirianMohammad Abdollahi
Nov 8, 2014·Journal of Traditional and Complementary Medicine·Selvaraju SubashGilles J Guillemin
Feb 26, 2013·The Science of the Total Environment·Julia Blanco-MuñozMarina Lacasaña
Oct 18, 2011·Toxicology Letters·G RamaRao, B K Bhattacharya
Aug 26, 2011·Ecotoxicology and Environmental Safety·Anupama Ojha, Nalini Srivastava
Aug 17, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ana FerrariAndrés Venturino
Mar 30, 2010·Reproductive Toxicology·Guadalupe Gallegos-AvilaGilberto Jaramillo-Rangel
Aug 4, 2009·The Science of the Total Environment·G Moreno-BandaO Pérez-Méndez
Jul 21, 2009·Toxicology and Applied Pharmacology·Snjezana Zaja-MilatovicDejan Milatovic
Apr 28, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sibel OzdenBuket Alpertunga
Jan 9, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Devendra K RaiBechan Sharma
Oct 20, 2015·Cell Stress & Chaperones·Intidhar Ben SalemSalwa Abid Essefi
Mar 14, 2008·Ecotoxicology and Environmental Safety·Murat KanburSibel Silici
Oct 9, 2007·Neurotoxicology·Yoram FinkelsteinMichael Aschner
Aug 21, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Anna Lukaszewicz-Hussain
Aug 4, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Davor ZeljezićNevenka Kopjar
Dec 21, 2006·Toxicology and Applied Pharmacology·Jing LiuCarey Pope

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