Anticipated impact of stem cell and other cellular medicine clinical trials for COVID-19.

Regenerative Medicine
Mina Kim, Paul S Knoepfler

Abstract

Aim: There is a critical need for safe and effective treatments for COVID-19. One possible type of treatment is cellular medicine such as stem cell therapy, but its potential is unclear. Here, our aim was to assess the potential impact of the many cellular medicine trials for COVID-19. Materials & methods: We collected and analyzed data for defined criteria from trial registries. Results: Our data suggest that relatively few of these COVID-19 trials will produce high-level evidence, but that on average they may be somewhat more rigorous than typical cell therapy trials unrelated to COVID-19. Conclusion: Most COVID-19 cellular medicine trials have relatively low potential for rapid, concrete impact. We discuss the findings in the context of the cellular medicine field overall.

References

Aug 8, 2015·BMC Biotechnology·Brittany P Dodson, Aaron D Levine
Jul 5, 2016·Cell Stem Cell·Leigh Turner, Paul Knoepfler
Mar 8, 2018·The New England Journal of Medicine·Peter Marks, Scott Gottlieb
Feb 6, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Joanne KurtzbergUNKNOWN MSB-GVHD001/002 Study Group
Apr 9, 2020·The European Respiratory Journal·Maroun KhouryDaniel J Weiss
Apr 25, 2020·Science·Alex John London, Jonathan Kimmelman
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Aug 21, 2020·Regenerative Medicine·Elizabeth RichardsonZubin Master
Sep 19, 2020·Science·Christi J GuerriniPatricia J Zettler
Dec 3, 2020·The New England Journal of Medicine·David C Fajgenbaum, Carl H June

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