Anticipating potential linezolid-SSRI interactions in the general hospital setting: an MAOI in disguise

Mayo Clinic Proceedings
Christopher L SolaTimothy W Lineberry

Abstract

Linezolid, a novel antimicrobial with activity against gram-positive bacteria including pathogens resistant to traditional antimicrobials, also inhibits monoamine oxidase. This latter property can cause potentially lethal adverse interactions with antidepressant medications. Long known to psychiatrists, monoamine oxidase inhibitors (MAOIs) and complications of their use may be unfamiliar to medical and surgical practitioners who may thus unwittingly precipitate a hypertensive crisis or serotonin syndrome. We review the pharmacology of MAOis and describe 3 clinical situations In which linezolid-selective serotonin inhibitor (SSRI) interactions, actual or potential, figured prominently.

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Citations

Mar 25, 2008·Therapeutics and Clinical Risk Management·Roberto Manfredi
Mar 1, 2012·The Psychiatric Clinics of North America·Sandra Rackley, J Michael Bostwick
Aug 14, 2009·Journal of Affective Disorders·Raymond W LamUNKNOWN Canadian Network for Mood and Anxiety Treatments (CANMAT)
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Feb 21, 2013·The Annals of Pharmacotherapy·Melanie R Woytowish, Lena M Maynor
Mar 8, 2013·The Journal of Head Trauma Rehabilitation·Jaime M Levine
Apr 19, 2020·Journal of Clinical Pharmacy and Therapeutics·Cristina Corsini CampioliIrene G Sia
Nov 2, 2011·Annals of the Royal College of Surgeons of England·Z S ShaikhT J Malins
Jun 30, 2019·Journal of Leukocyte Biology·Kehong ZhangXinchun Chen

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