PMID: 9184310May 31, 1997Paper

Anticipation in schizophrenia: biology or bias?

American Journal of Medical Genetics
J E JohnsonC A Kaufmann

Abstract

Anticipation is a genetic phenomenon wherein age of disease onset decreases and/ or severity increases in successive generations. Anticipation has been demonstrated for several neuropsychiatric disorders with expanding trinucleotide repeats recently identified as the underlying molecular mechanism. We report here the results of an analysis of anticipation performed with multiplex families segregating schizophrenia. Thirty-three families were identified through the NIMH Genetics Initiative that met the following criteria: had at least two affected members in successive generations and were not bilineal. Affectation diagnoses included schizophrenia, schizoaffective disorder-depressed, and psychosis NOS. Additional analyses included the Cluster A personality disorders. Three indices of age of onset were used. Disease severity was measured by several different indices. Four sampling schemes as suggested by McInnis et al. were tested, as well as additional analysis using pairs ascertained through the parental generation. Anticipation was demonstrated for age of onset, regardless of the index or sampling scheme used (P<0.05). Anticipation was not supported for disease severity. Analyses that took into account drug use and diminished ...Continue Reading

References

Sep 4, 1992·Cell·R I Richards, G R Sutherland
Jan 1, 1991·Journal of Psychiatric Research·M G WarshawP W Lavori
Feb 1, 1984·Archives of General Psychiatry·A W Loranger
Jan 1, 1982·Archiv für Psychiatrie und Nervenkrankheiten·F HaverkampT Hilger
Aug 1, 1995·Nature Genetics·M C O'DonovanP McGuffin
Jul 1, 1993·Trends in Neurosciences·C A RossS H Li
May 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·P AshersonP McGuffin
Jun 15, 1994·American Journal of Medical Genetics·C R Cloninger
Jan 1, 1994·Pediatric Pathology·S Langlois
Oct 1, 1993·Archives of General Psychiatry·K S KendlerD Walsh

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Citations

Oct 13, 2001·Schizophrenia Bulletin·D Malaspina
Apr 4, 2001·Psychiatry and Clinical Neurosciences·C H LinC J Hong
Oct 11, 2002·Mayo Clinic Proceedings·Janet L SobellCynthia T McMurray
Apr 8, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Elizabeth HareMichael A Escamilla
Dec 3, 1999·American Journal of Medical Genetics·M G McInnisL E DeLisi
May 17, 2000·American Journal of Medical Genetics·J B VincentJ L Kennedy
Apr 3, 2002·Journal of Biosciences·Suman PrasadB K Thelma
Mar 29, 2005·Academic Medicine : Journal of the Association of American Medical Colleges·Diane C CallesonSarena D Seifer
Mar 31, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·M R KamyaP J Rosenthal
Feb 25, 2000·American Journal of Medical Genetics·H H Stassen, C Scharfetter
Jun 24, 2004·CNS Spectrums·Kezia J Lange, Melvin G McInnis
Jun 1, 2005·Irish Journal of Psychological Medicine·Brendan D Kelly

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