Anticipation of onset age in familial Parkinson's disease without SCA gene mutations

Parkinsonism & Related Disorders
Yue HuangGlenda M Halliday

Abstract

Assessment of a series of 279 cases with Lewy body disease revealed 14 families having a family history consistent with autosomal dominant inheritance, eight of these with dominant Parkinsonism and six with dominant dementia. Analysis of the age at onset and genetic features in these families revealed significant anticipation only in a subset of parkinsonian families, with no pathological alleles for spinocerebellar ataxias or the common alpha-synuclein or LRRK2 point mutations.

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Citations

Feb 18, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Monica FederoffAndrew Singleton
Feb 24, 2015·Trends in Genetics : TIG·Aline VerstraetenChristine Van Broeckhoven

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