Anticoagulant activity of a bacterial glycopeptide

Thrombosis Research
A AkoumM Sigot

Abstract

The anticoagulant properties of myxalin, a glycopeptide secreted by a Gram negative bacterium strain (Myxococcus xanthus) are studied and compared to those of heparin. This soluble material exhibits an anticoagulant activity which implies the inhibition of some serine proteases, thrombin and factor Xa. In the presence of normal and antithrombin III-depleted plasma, myxalin inhibits the amidolytic activity of thrombin on synthetic chromogenic substrate as a function of its concentration, but fails to increase thrombin inactivation significantly in the presence of purified AT III. However, crossed immunoelectrophoresis data suggests that its antithrombi effect is mainly mediated by binding to the enzyme, rather than to AT III and probably differs from the catalytic activity of heparin which requires the presence of AT III. The anticoagulant process occurs without degradation of fibrinogen and can be neutralized by protamine.

References

Jan 1, 1979·Annual Review of Microbiology·D KaiserM Dworkin
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·U LindahlA Linker
Apr 2, 1974·Archives of Biochemistry and Biophysics·G F Briginshaw, J N Shanberge
Sep 1, 1981·The Journal of Clinical Investigation·D M Tollefsen, M K Blank
Oct 1, 1982·Biomaterials·M MauzacJ Jozefonvicz

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Citations

Feb 11, 2003·Biological & Pharmaceutical Bulletin·Yu Lin GouHsiao Chang Chan
Sep 1, 1995·In Vitro Cellular & Developmental Biology. Animal·A AkoumR Roy
Apr 1, 1992·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·A AkoumM F Sigot-Luizard

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