Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N-sulfate content

Journal of Biomedical Materials Research
L C SederelA Bantjes

Abstract

Addition of chlorosulfonyl isocyanate to C==C bonds in cis-1,4-polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water-soluble polyelectrolyte with N-sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N-sulfate content.

References

Nov 29, 1978·Biochemical and Biophysical Research Communications·M W PiepkornG Schmer
Nov 1, 1978·The Biochemical Journal·T C LaurentU Lindahl
Jan 1, 1975·Advances in Experimental Medicine and Biology·J A Cifonelli
Nov 1, 1974·Journal of Biomedical Materials Research·T BeugelingW L Sederel
Aug 1, 1966·Archives of Biochemistry and Biophysics·S E Lasker, S S Stivala

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Citations

Nov 1, 1991·Journal of Biomedical Materials Research·Y ItoY Imanishi
Jan 24, 2002·Biomaterials·Yasushi TamadaKohei Goto
Jun 1, 2000·Journal of Inorganic Biochemistry·Y Ito
Mar 1, 1989·Journal of Biomedical Materials Research·T G Grasel, S L Cooper
Oct 3, 2006·European Journal of Medicinal Chemistry·Claudio SalvagniniJacqueline Marchand-Brynaert
Mar 29, 2007·The Journal of Physical Chemistry. B·Grigoris MountrichasStergios Pispas

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