PMID: 11920761Mar 29, 2002Paper

Anticoagulant activity of heparin following oral administration of heparin-loaded microparticles in rabbits

Journal of Pharmaceutical Sciences
Yuyan JiaoP Maincent

Abstract

Heparin-loaded microparticles, prepared according to the double emulsion method with biodegradable (PCL and PLGA) and nonbiodegradable (Eudragit RS and RL) polymers used alone or in combination, with or without gelatin, were characterized in vitro and in vivo after oral administration in rabbits. The entrapment efficiency and the release of heparin were determined by a colorimetric method with Azure II. The antifactor Xa activity of heparin released in vitro after 24 h was assessed. After oral administration of heparin-loaded microparticles in rabbits, the time course of modification of the clotting time estimated by the activated partial thromboplastin time (APTT) was followed over 24 h. Microparticles with a size ranging from 80 to 280 microm were obtained. Heparin entrapment efficiency as well as heparin release depended on both the nature of the polymers and the presence of gelatin. The Eudragit polymers increased the drug loading but slowed down the heparin release, whereas gelatin accelerated the release. No change in clotting time was observed after oral administration of gelatin microparticles. Heparin-loaded microparticles prepared with blends of PLGA and Eudragit displayed a prolonged duration of action characterized ...Continue Reading

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Citations

Mar 21, 2007·Pharmaceutical Research·Vjera GrabovacAndreas Bernkop-Schnürch
May 8, 2013·Pharmaceutical Research·Angela Viehof, Alf Lamprecht
Jul 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yiwei QiRam Sasisekharan
Sep 1, 2007·Journal of Microencapsulation·Miha HomarPhilippe Maincent
Oct 11, 2008·Journal of Microencapsulation·Satya Surya Shankar LankeMartin J D'souza
Jan 29, 2013·Journal of Drug Targeting·Canan IskenderoğluYeşim Bardakçi
Nov 26, 2009·Drug Development and Industrial Pharmacy·Julien Scala-BertolaPhilippe Maincent
May 28, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·L JavotP Maincent
May 19, 2009·International Journal of Pharmaceutics·J Scala-BertolaP Maincent
Sep 22, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sang Kyoon KimYoungro Byun
Jun 2, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Alf LamprechtPhilippe Maincent
May 11, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sang Kyoon KimYoungro Byun
Dec 8, 2006·International Journal of Pharmaceutics·Yvette MeissnerAlf Lamprecht
Jul 8, 2015·Therapeutic Delivery·Bettina Ralay-RanaivoRuxandra Gref
Oct 30, 2007·The Journal of Toxicological Sciences·Choong-Yong KimYoungro Byun
Jul 2, 2016·Pharmaceuticals·Ana Rita NevesMadalena Pinto
Nov 5, 2016·International Journal of Pharmaceutics·Samiha MouftahAlf Lamprecht
Apr 19, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ayca Yildiz-Pekoz, Yildiz Ozsoy
Jun 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eleonora TruzziEliana Leo
May 1, 2021·International Journal of Molecular Sciences·Xiao-Lei QiuChun-Xia Li

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