Anticoagulant activity of sulfoalkyl derivatives of curdlan

Archives of Pharmacal Research
K B LeeY S Kim

Abstract

Curdlan is a natural beta-1,3-glucan produced by Agrobacterium biovar 1. In this study, the anticoagulant activity of sulfoalkyl derivatives of curdlan was investigated by carrying out activated partial thromboplastin time (APTT) assay and compared with that of o-sulfonated curdlan. Approximately 100-fold higher concentration of o-sulfonated curdlan than heparin was required to obtain the same level of the clotting time. Anticoagulant activity of curdlan derivatives was dependent on the degree of sulfation in prolonging the clotting time. However, the chain length of the substituent did not play a role in prolonging the clotting time. The curdlan derivatives enhanced thrombin inhibition by mediating through antithrombin III. The inhibition of thrombin by o-sulfonated curdlan was found to be approximately 10-fold weaker than that by heparin.

References

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Citations

Sep 18, 2012·Food Chemistry·Shengjun WuYuying Sun
Oct 23, 2012·International Journal of Biological Macromolecules·Longfa Jiang
Jul 1, 2010·Prikladnaia biokhimiia i mikrobiologiia·N M Mestechkina, V D Shcherbukhin
May 1, 2021·Nutrients·Shafaque RahmanSigrid E M Heinsbroek
Jan 20, 2009·International Journal of Biological Macromolecules·Georgeta MocanuDidier LeCerf

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