Anticoagulant effects of a Cannabis extract in an obese rat model

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
C CoetzeeC L Frost

Abstract

Blood coagulation studies were conducted to determine the possible anti-/prothrombotic effect of an organic cannabis extract and the three major cannabinoids, THC, CBD and CBN. The in vitro effect of the cannabis extract on thrombin activity produced an IC50 value of 9.89 mg/ml, compared to THC at 1.79 mg/ml. It was also found that the extract, THC and CBN showed considerable inhibition of thrombin-induced clot formation in vitro with IC50 values of 600, 87 and 83 microg/ml for the extract, THC and CBN respectively. In an in vivo model used to determine clotting times of lean and obese rats treated with a cannabis extract, 50% clotting times were found to be 1.5 and 2 fold greater than their respective control groups, supporting the results obtained in the in vitro model. The study thus shows that Cannabis sativa and the cannabinoids, THC and CBN, display anticoagulant activity and may be useful in the treatment of diseases such as type 2 diabetes in which a hypercoagulable state exists.

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Citations

Dec 20, 2012·International Journal of Endocrinology·Ahmet Levent BasEzgi Ermis Kaya
Oct 25, 2014·Annals of the American Thoracic Society·Andrew W MurrayJames W Ibinson
Mar 17, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R-A LevendalC L Frost
Apr 7, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M GallantR-A Levendal
May 14, 2014·The Journal of Pharmacy and Pharmacology·Natasha BeukesCarminita L Frost
Nov 29, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xuan LuoCuiwu Lin
Apr 2, 2020·International Journal of Environmental Research and Public Health·Anna TzortziPanagiotis Beghrakis
Dec 25, 2019·Cannabis and Cannabinoid Research·Karim S LadhaHance Clarke
Aug 21, 2021·JACC. Cardiovascular Interventions·Mamas A Mamas, Pablo Lamelas
Oct 11, 2017·The American Journal of Emergency Medicine·Amar Shere, Hemant Goyal
Mar 11, 2019·Journal of Clinical Anesthesia·Marco Echeverria-VillalobosSergio D Bergese
Feb 2, 2022·JBJS Reviews·Sean G SheppardWilliam Kent
Sep 19, 2018·Heliyon·Henry B HusonYvonne Rasko

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