PMID: 8599189Oct 1, 1995Paper

Anticoagulant effects of Pseudechis australis (Australian king brown snake) venom on human blood: a computerized thromboelastography study

Toxicon : Official Journal of the International Society on Toxinology
Y M DambisyaP Gopalakrishnakone

Abstract

The crude venom of Pseudechis australis exhibited a dose-dependent anticoagulant action on human blood in vitro using computerized thromboelastography. Clot progress parameters (K and alpha) were affected at low dose levels which had no effect on onset of coagulation parameters (SP, R). At high dose levels there was total anticoagulant effect, but in all cases there was no evidence of fibrinolytic activity. These results generally agree with the known effects of this venom on coagulation in vivo, and further support our earlier suggestion that TEG may be a useful, one-step tool in the diagnosis and monitoring of the progress of envenomation patients.

References

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Citations

Jun 13, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Richard StoneOliver Marshall
Jan 27, 1999·Toxicon : Official Journal of the International Society on Toxinology·B G Fry
Mar 20, 1999·Biochimica Et Biophysica Acta·B R JenningsE G Shephard
Mar 23, 2011·Journal of Proteome Research·Dessislava GeorgievaChristian Betzel
Feb 26, 2005·Clinical and Experimental Pharmacology & Physiology·Sharmaine RamasamyWayne C Hodgson
Apr 15, 2014·Toxicon : Official Journal of the International Society on Toxinology·Shahab RazaviJulian White
Apr 17, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·C I JohnstonUNKNOWN ASP investigators
Sep 5, 2003·Rapid Communications in Mass Spectrometry : RCM·Bryan G FryR Manjunatha Kini
Jun 3, 2005·Molecular Biology and Evolution·Liam St PierreMartin F Lavin
Jan 26, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sébastien LarréchéChristophe Martinaud
Mar 22, 2020·International Journal of Molecular Sciences·Vance G NielsenNathaniel Frank
Sep 20, 2005·Toxicon : Official Journal of the International Society on Toxinology·Brent JenningsEnid Shephard

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